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Environmental signal integration by a modular AND gate

Environmental signal integration by a modular AND gate. J Christopher Anderson, Christopher A Voigt and Adam P Arkin Molecular Systems Biology (2007) 3:133. AND gate. Amber stop codon.

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Environmental signal integration by a modular AND gate

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  1. Environmental signal integration by a modular AND gate J Christopher Anderson, Christopher A Voigt and Adam P Arkin Molecular Systems Biology (2007) 3:133

  2. AND gate

  3. Amber stop codon Nonsense mutation = point mutation in DNA sequence resulting in premature stop codon or nonsense codon in transcribed mRNA -> truncated/non-functional protein product. Supressor = tRNA that can “read” nonsense codon and cause appropriate amino acid to be incorporated into peptide sequence.

  4. Functionality

  5. Mathematical model

  6. Modularity

  7. Concluding remarks Independent promoters detecting different aspects of the environment (O2, pH, cell density, lactate, glucose) could be integrated to sense a specific environment.

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