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Lab #5 Preparation of effervescent granules

Lab #5 Preparation of effervescent granules. Presentation to students of health college Monday, April 04, 2010. by: TA/ Mohammad Al-Mermesh, BSc., PGC,. Prepare 20 gm of effervescent base sodium Bicarbonate 53 % citric acid 19 %

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Lab #5 Preparation of effervescent granules

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  1. Lab#5Preparation of effervescent granules Presentation tostudents of health college Monday, April 04, 2010 by: TA/ Mohammad Al-Mermesh, BSc., PGC,

  2. Prepare 20 gm of effervescent base • sodium Bicarbonate 53 % • citric acid 19 % • tartaric acid 28 % Calculations: Prepare 25 gm & 5 gm extra …. Base alone Sodium bicarbonate = 25 x 53/100 = 13.25 gm Citric acid = 25 x 19/100 = 4.75 gm Tartaric acid = 25 x 28/100 = 7 gm Alcohol = 25 x 15 ml/100 = 3.75 ml

  3. Prepare 20 gm of effervescent granules containing 10 % Iron Ammonium citrate Calculations: Base + drug Drug = 25 x 10/100 = 2.5 gm Wight of the base = 25 – 2.5 = 22.5 gm Wight of sodium bicarbonate = 22.5 x 53/100 = 11.9 gm Wight of citric acid = 22.5 – 19/100 = 4.3 gm Wight of tataric acid = 22.5 x 28/100 = 6.3

  4. Procedure: • Weigh the required amount of all ingredients (sod., citric, tartaric), grind the powder in mortar to finely ground powder then pass through sieve no. 60 • Mix all ingredient powders homogenously in a porcelain mortar, then add wetting agent (alcohol 95 %) to form coherent mass • The coherent mass passed through sieve no 12, by pressing in one direction • the collected granules are dried in a hot oven of 40° C for 10 • Pack the final product I a specific container

  5. Uses: Iron deficiency anemia Role of each ingredients: Iron: Active Ingredient Citric Tartaric Sod. Alcohol: Moistening Agent } Base

  6. Thank You

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