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G-Protein Coupled Receptors, Taste, and Miracle Fruit

G-Protein Coupled Receptors, Taste, and Miracle Fruit. Last night’s Homework. Name the 5 types of taste. Explain why each type of taste was important in human evolution. Salty – maintaining water balance. Sweet – detecting ripe fruit. Sour – detecting unripe fruit.

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G-Protein Coupled Receptors, Taste, and Miracle Fruit

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  1. G-Protein Coupled Receptors, Taste, and Miracle Fruit

  2. Last night’s Homework • Name the 5 types of taste. Explain why each type of taste was important in human evolution. Salty – maintaining water balance Sweet – detecting ripe fruit Sour – detecting unripe fruit Bitter – detecting poison Umami – detecting protein

  3. How do we taste? Bitter Salt Each taste bud is thought to contain all types of receptors Sweet Umami Sour

  4. controlttTt TT Nontaster (tt) GGCGGGCACT (221 bp long) Taster gene (TT) GGCGGCCACT When cut with restriction enzyme Hae III between GGCC what happens???? 221 bp 176 bp 45 bp

  5. Taste evolution • Primates have both tasters and nontasters • All monkeys are tasters and don’t taste aspartame as sweet

  6. Almost all vertebrates can taste sweet and umami • Cats and chickens cannot detect sweet foods • Bats that eat different foods have different genes expressed – fruit bats have active sweet receptor genes and not umami)

  7. Pandas They are BEARS with large canine teeth with no ability to digest vegetable matter and no chambered stomachs. Which came first – the preference for bamboo diet or the mutated umami gene??? If the receptor was restored to functional, what effect might this have on the panda?

  8. GCPR for taste • 3. Umami • 1. Bitter • 2. Sweet

  9. Let’s taste-test • Miracle Berries and Gymnema Tea

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