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Regulation of Calcium Channels by G Protein-Coupled Receptors

membrane potential. enzymes. gene transcription. excitation-contraction. exocytosis. Regulation of Calcium Channels by G Protein-Coupled Receptors. Transmitters decrease the calcium component of sensory neurone action potentials.

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Regulation of Calcium Channels by G Protein-Coupled Receptors

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  1. membrane potential enzymes gene transcription excitation-contraction exocytosis Regulation of Calcium Channels by G Protein-Coupled Receptors

  2. Transmitters decrease the calcium component of sensory neurone action potentials Dunlap K, Fischbach GD. Neurotransmitters decrease the calcium component of sensory neurone action potentials. Nature. 1978 Dec;276(5690):837-839.

  3. Calcium channels are multimeric proteins Strock J, Diverse-Pierluissi MA. Ca2+ channels as integrators of G protein-mediated signaling in neurons. Mol Pharmacol. 2004 Nov;66(5):1071-1076. Epub 2004 Jul 21.

  4. Classification of high-voltage activated calcium channels Name Previous Alpha 1 Blocker Localization Function Name Cav1.1 L a1S DHP Skeletal muscle Excitation-contraction, Gene regulation Cav1.2 L a1C DHP Heart, endo., neurons Excitation-contraction, Hormone secretion Cav1.3 L a1D DHP Endocrine cells and neurons Hormone secretion, Gene regulation Cav1.4 L a1F Retina Tonic transmitter release Cav2.1 P/Q a1A w-Ag Neurons Exocytosis Cav2.2 N a1B w -Con Neurons Exocytosis Cav2.3 R a1E SNX482 Neurons Exocytosis Strock J, Diverse-Pierluissi MA. Ca2+ channels as integrators of G protein-mediated signaling in neurons. Mol Pharmacol. 2004 Nov;66(5):1071-1076. Epub 2004 Jul 21.

  5. Active zones contain calcium channels and synaptic vesicles that interact with adaptor proteins

  6. Multiple G protein-mediated pathways inhibit voltage-dependent calcium channels Strock J, Diverse-Pierluissi MA. Ca2+ channels as integrators of G protein-mediated signaling in neurons. Mol Pharmacol. 2004 Nov;66(5):1071-1076. Epub 2004 Jul 21.

  7. Cytoplasmic domains of the alpha 1 subunit of the calcium channel

  8. Proteins that interact with the cytoplasmic domains of the alpha 1 subunit of the calcium channel can interact with each other

  9. Proteins that interact with the cytoplasmic domains of the alpha 1 subunit of the calcium channel Strock J, Diverse-Pierluissi MA. Ca2+ channels as integrators of G protein-mediated signaling in neurons. Mol Pharmacol. 2004 Nov;66(5):1071-1076. Epub 2004 Jul 21.

  10. Interaction of Gbg with the calcium channel mediates transmitter-induced voltage-dependent inhibition of calcium current Jarvis SE, Zamponi GW. Interactions between presynaptic Ca2+ channels, cytoplasmic messengers and proteins of the synaptic vesicle release complex. Trends Pharmacol Sci. 2001 Oct;22(10):519-525.

  11. Binding of Gbg to the calcium channel displaces the beta subunit of the calcium channel Zamponi GW, Snutch TP. Modulation of voltage-dependent calcium channels by G proteins. Curr Opin Neurobiol. 1998 Jun;8(3):351-356.

  12. Interaction of Gbg with the calcium channel induces the “reluctant” state Zamponi GW, Snutch TP. Modulation of voltage-dependent calcium channels by G proteins. Curr Opin Neurobiol. 1998 Jun;8(3):351-356.

  13. Cross-talk beween Gbg and protein kinase C in the modulation of calcium current Cooper CB, Arnot MI, Feng ZP, Jarvis SE, Hamid J, Zamponi GW. Cross-talk between G-protein and protein kinase C modulation of N-type calcium channels is dependent on the G-protein beta subunit isoform. J Biol Chem. 2000 Dec;275(52):40777-40781.

  14. Cross-talk beween Gbg and protein kinase C in the modulation of calcium current is dependent on the type of Gb Cooper CB, Arnot MI, Feng ZP, Jarvis SE, Hamid J, Zamponi GW. Cross-talk between G-protein and protein kinase C modulation of N-type calcium channels is dependent on the G-protein beta subunit isoform. J Biol Chem. 2000 Dec;275(52):40777-40781.

  15. Dual regulation of voltage-gated calcium channels by PtdIns (4,5)P2 Wu L, Bauer CS, Zhen XG, Xie C, Yang J. Nature. 2002 Oct;419(6910):947-952.

  16. Stabilization of P/Q calcium current by PIP2 Tail current can be used to measure functional channels PIP2 slowed down rundown after patch excision Mg-ATP slowed down rundown after patch excision Wu L, Bauer CS, Zhen XG, Xie C, Yang J. Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.Nature. 2002 Oct;419(6910):947-952.

  17. PtdIns (4,5)P2 induced voltage-dependent inhibition Wu L, Bauer CS, Zhen XG, Xie C, Yang J. Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.Nature. 2002 Oct;419(6910):947-952.

  18. Receptor-mediated PIP2 hydrolysis: LHRH in frog sympathetic neurons Inhibition of PLC of U732122 Inhibition is voltage-independent Wu L, Bauer CS, Zhen XG, Xie C, Yang J. Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.Nature. 2002 Oct;419(6910):947-952.

  19. Multiple G protein coupled receptors mediate the inhibition of neuronal calcium channels Strock J, Diverse-Pierluissi MA. Ca2+ channels as integrators of G protein-mediated signaling in neurons. Mol Pharmacol. 2004 Nov;66(5):1071-1076. Epub 2004 Jul 21.

  20. Binding of SNARE proteins to neuronal calcium channels “willing” “reluctant”

  21. Muth JN, Varadi G, Schwartz A. Use of transgenic mice to study voltage-dependent Ca2+ channels. Trends Pharmacol Sci. 2001 Oct;22(10):526-532.

  22. Muth JN, Varadi G, Schwartz A. Use of transgenic mice to study voltage-dependent Ca2+ channels.Trends Pharmacol Sci. 2001 Oct;22(10):526-532.

  23. Time course of GABA-B receptor-mediated inhibition of N type current Diverse-Pierluissi M, Remmers AE, Neubig RR, Dunlap K. Novel form of crosstalk between G protein and tyrosine kinase pathways. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5417-21.

  24. PI3K promotes voltage dependent calcium channel trafficking in the plasma membrane Viard P, Butcher AJ, Halet G, Davies A, Nurnberg B, Heblich F, Dolphin AC. Nat Neurosci. 2004 Sep;7(9):939-946.

  25. Effect of PI3K-induced production of PIP3 on Cav1.2/2a currents Viard P, Butcher AJ, Halet G, Davies A, Nurnberg B, Heblich F, Dolphin AC. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci. 2004 Sep;7(9):939-946.

  26. Effect of PI3K on Calcium Channel Membrane Localization Viard P, Butcher AJ, Halet G, Davies A, Nurnberg B, Heblich F, Dolphin AC. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci. 2004 Sep;7(9):939-946.

  27. Effect of S574A mutation on the PI3K and myr-Akt/PKB-induced regulation of Cav2.2 channels Viard P, Butcher AJ, Halet G, Davies A, Nurnberg B, Heblich F, Dolphin AC. PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nat Neurosci. 2004 Sep;7(9):939-946.

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