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Pulmonary Flow Resistive Device

A novel solution for Hypoplastic Left Heart Syndrome (HLHS) using a conical device in the pulmonary artery to increase systemic blood flow. Requires modeling and materials. Progress includes research, design plan, and prototype development.

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Pulmonary Flow Resistive Device

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  1. Pulmonary Flow Resistive Device Taya Furmanski Albert Attia Advisor: Tom Doyle, MD January 15, 2003

  2. Background • Hypoplastic Left Heart Syndrome (HLHS) is a condition in which the patient is missing his/her left ventricle • Occurs in 0.036% of live births • Approximately 75% 3-year survival rate • No medical treatment for HLHS • Only options are operation (reconstruction) or transplantation

  3. The Problem • Inadequate systemic blood flow • Amount of O2 delivered to the organs significantly decreased • Hence the term “Blue Baby”

  4. How to Solve the Problem • Place conical shaped device in the pulmonary artery • Device will act as resistor • Decrease in pulmonary blood flow will cause increase in systemic blood flow

  5. What We Need- Modeling - • System (computer or physical) that models the blood vessels • Prototype can be tested through model to determine effectiveness • Computer model would allow variables to be altered easily to determine the optimal dimensions of the device

  6. Blood Vessel Model

  7. What We Need- Materials & Assistance - • Nitinol wire (of various gauges) • Using outside vendors or Vanderbilt shop to mold conical device • Find experienced programmer to develop computer modeling system – or use one currently in existence • Use materials to create physical model that accurately portrays operation of device

  8. What We Have Accomplished Thus Far… • In-depth research of HLHS • Several meetings with Dr. Doyle to discuss the problem and possible solutions • Finalizing a design plan • Create a plan of attack: start simple and increase complexity

  9. What We Have Yet to Do… • Use all sources to accomplish these goals • Have working prototype completed by beginning of March • Finalize design specs • Continue meetings with Dr. Doyle

  10. References • Barber, Gerald. Hypoplastic Left Heart Syndrome. Structural Congenital Defects, section 3. • http://www.chop.edu/about_chop/preview/images/hypo_heart.gif; date accessed: January 14, 2003

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