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Metals in Medicine Research University of Wollongong

Institute for Biomolecular Science (IBS) 14 Academic Staff Dept. of Chemistry Dept. of Biology 9 Postdocs 30 PhD Students B. Med Chem B. Biotech . Project areas include: Drug design and development Biomolecular structure determination Cellular and molecular biology

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Metals in Medicine Research University of Wollongong

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  1. Institute for Biomolecular Science (IBS) 14 Academic Staff Dept. of Chemistry Dept. of Biology 9 Postdocs 30 PhD Students B. Med Chem B. Biotech Project areas include: Drug design and development Biomolecular structure determination Cellular and molecular biology Food and natural product chemistry Mechanism of cataract formation Metals in Medicine Research University of Wollongong

  2. Interactions of Gold Drugs with Proteins

  3. How does Chrysotherapy Work? • Many possible mechanisms of action: • Anti-inflammatory • Inhibition of lysosomal enzymes • Immunomodulatory activity • Effects on metabolism of reactive oxygen • All gold drugs rapidly bind to proteins containing thiol side chains, but not DNA. • [Au(CN)2]- is a common metabolite of all Au drugs • Au(I) oxidised to Au(III) in vivo

  4. ESI-MS of Human Serum Albumin (HSA) J. Croft, CHEM340, 2004

  5. Reaction between [Au(PEt3)Cl] and Metallothionein S. Ambehara, B.Sc(Hons), 20002

  6. Covalent Binding of Ruthenium Compounds to DNA J. Torrens, B.Sc(Hons), 2000

  7. Non-covalent Interactions Between Ruthenium Complexes and DNA J. Aldrich-Wright and co-workers

  8. ESI-MS of D2 [D2-6H]6- [D2-5H]5- T. Urathamakul, B.Sc(Hons), 2002

  9. ESI-MS of [Ru(phen)2(dpqC)]2+(mol. wt = 748) T. Urathamakul, B.Sc(Hons), 2002

  10. Reactions between [Ru(phen)3]2+ and D2 T. Urathamakul, B.Sc(Hons), 2002 Ru:D2 = 5:1 Ru:D2 = 10:1 Ru:D2 = 20:1 Ru:D2 = 30:1 Ru:D2 = 50:1

  11. Reactions between [Ru(phen)2L]2+ and D2 L = phen L = pda L = dpq L = dpqMe2 L = dpqC T. Urathamakul B.Sc(Hons), 2002 L = dppz

  12. Future Work • Binding of mono- and poly-nuclear ruthenium complexes to longer DNA and DNA containing other base sequences • Binding of gold, vanadium, bismuth, ruthenium and other metal-containing drugs to proteins including HSA, MT and Transferrin

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