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NSF-NIEHS Centers for Oceans and Human Health

NSF-NIEHS Centers for Oceans and Human Health. - Novel integration of NIH and NSF. Stimulated by scientific community, and by CORE, an NRC report, and the Directors of NSF and NIEHS. Focus on HAB, pathogens, pharmaceuticals, - Integrate biological / oceanographic approaches.

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NSF-NIEHS Centers for Oceans and Human Health

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  1. NSF-NIEHS Centers for Oceans and Human Health - Novel integration of NIH and NSF. Stimulated by scientific community, and by CORE, an NRC report, and the Directors of NSF and NIEHS. Focus on HAB, pathogens, pharmaceuticals, - Integrate biological / oceanographic approaches.

  2. NSF-NIEHS Centers for Oceans and Human Health Joint Request for Applications (RFA) Competitive review of Center grant applications. 20 plus applications Four Centers funded: Washington Hawaii Woods Hole Miami

  3. Woods Hole Centerfor Oceans and Human Health Integrated effort by three Institutions: Woods Hole Oceanographic Inst. Marine Biological Laboratory Massachusetts Inst. of Technology

  4. Woods Hole Center for Oceans and Human Health

  5. Research Focus Harmful algal blooms (2 projects) Infectious agents (2 projects) Temperate Coastal Waters New England waters as a model system.

  6. Woods Hole Center for Oceans and Human Health Administrative Core Stegeman McGillicuddy Advanced Genomics Population Biology Coastal Hydrodynamics 1. Anderson: HABs 2. McGillicuddy: HABs Core Facility Sogin Morrison 3. Gast and Amaral-Zettler: Infectious Diseases 4. Polz and Lerczak: Infectious Diseases Pilot Projects Director: Hajduk co-Director: Hahn

  7. WHOI MBL MIT Woods Hole Center for Oceans and Human Health Other Institutes & Centers EHS Centers Other COHH

  8. Human Pathogens in the Environment • -reservoirs • -favorable growth • Gene transfer ? environmental amplification Shellfish poisoning, toxicosis…. transport understanding ecology = understanding risk --> prediction and prevention

  9. Mt. Hope Bay • Heavily impacted by humans • Sewage outfalls, industrial waste, thermal discharge • Mt. Hope Bay Natural Laboratory • Centralized data bases • Predictive current models under development • No microbial or pathogen sampling program • Proxy for other New England bays

  10. Vibrio infections - a worldwide problem Environmental reservoirs, routes of transmission and infection WH-COHH Vibrio project • Understand • Predict • Protect • Wound, eye and ear infection: • rising worldwide • - numbers not well known • - Environmental prevalence • and growth factors • Gene transfer and • evolution • Risk assessment V. vulnificus V. parahaemolyticus Seafood consumption: - up to 10,000 infections/yr in US and reports of infection rising (CDC); - 95% of all seafood related deaths

  11. Human Pathogens: Presence & Persistence in the Coastal Marine Environment • Studies of traditionally non-marine human pathogens in coastal marine waters: • Essential to determine their potential to impact human health • Evidence and vectors • Sea otters, whales, and shellfish can harbor protistan pathogens such as Giardia and Cryptosporidium • Shellfish and protists (such as Acanthamoeba) can harbor bacterial pathogens such as Legionella and Vibrio, and enhance pathogenicity. (Giardia) (Legionella in amoeba)

  12. HAB threats to human health in temperate waters of the northeastern U.S.

  13. Genotype Physical-biological coupled model Physiology Toxicity Woods Hole COHH HAB projects • Overall objective: to link dinoflagellate population structure, physiology, and toxicity in order to improve prediction and prevention of HABs. • Rationale: cellular toxicity varies with environmental and genetic factors; cell number is not always a good proxy for toxicity

  14. Paralytic shellfish poisoning (PSP) • causes paralysis and death; • causative organism Alexandrium fundyense (dinoflagellate); • widespread and recurrent annual problem; • ongoing shellfish monitoring programs in ME, NH, MA, CT

  15. Germination Only Germination, Growth, Mortality & Nutrient lim. Germination, Growth &Mortality May Jun Jul Aug

  16. Woods Hole Center for Oceans and Human Health Pilot Project Program Steve Hajduk (MBL), Director Mark Hahn (WHOI), Deputy Director 2004 Call for Proposals

  17. Pilot Project Program Objectives • Support short-term projects to assess feasibility of new research topics • Generate preliminary data • Expand scope of Center research • Expand participation in Center

  18. Pilot Project Program Areas of emphasis • Harmful algal blooms (HABs) • Water- and vector-borne diseases • Marine-derived pharmaceuticals and probes RFP: http://grants1.nih.gov/grants/guide/rfa-files/RFA-ES-03-003.html NRC/NAS (1999) From Monsoons to Microbes: Understanding the Ocean’s role in Human Health NSF/NIEHS Oceans and Human Health roundtable report, December 2001

  19. Pilot Project Program Eligibility • MBL, MIT, WHOI Scientific and Sr. Technical Staff

  20. Pilot Project Program Budgets • up to $50K direct costs • 1 year + no-cost extension if needed • Earliest start date: October 1, 2004 • Salaries • Supplies • Student stipend and tuition • Equipment - not usually • Travel - meetings: No • Travel - sample collection: If strongly justified • Ship time - if strongly justified

  21. Pilot Project Program Pre-proposal(required) • Due July 15, 2004 • 1 page summary of project • Direct and indirect costs • 2p CV/Biosketch for PI and other key personnel (NSF or NIH format) • Submit electronically: Steve Hajduk, MBL (shajduk@mbl.edu) or Mark Hahn, WHOI (mhahn@whoi.edu)

  22. Pilot Project Program Full proposals • Due August 15, 2004 at 5 PM EDT. • Title page • Research Plan (5 pp.)a) Objectives b) Background & Rationale c) Experimental design and methods d) Facilities available and/or use of genomics core e) Relevance to COHH program f) Broader impacts (see NSF guidelines) g) References (not included in 5p limit) • Budget (Direct and indirect costs) • Budget justification (1 p) • 2p CV/Biosketch for PI and other key personnel(NSF/NIH format) • Other support (Key personnel; NIH or NSF format) • Human subject / Vertebrate animal approvals • Submit hard copy (1) and electronically

  23. Pilot Project Program Review • Phase I- Woods Hole COHH Internal Advisory Committee (IAC)- outside reviewers (EAC) as needed- Written critiques • Phase II- presentations (10 min) to IAC

  24. Pilot Project Program Review criteria • Scientific merit • Relevance and potential impact • Innovation • Investigators • Facilities • Broader impacts

  25. Pilot Project Program Questions?

  26. Model run: cyst germination plus growth and mortality Present model assumes that all Alexandrium fundyense cells are the the same (i.e., same growth rate, nutrient responses, toxicity, motility, etc.) Will address different strains known to exist.

  27. Woods Hole COHH • Addressing public health issues. • Incorporating advanced genomic studies and oceanography.

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