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DNA

DNA. Unit Two. HISTORICAL DNA EXPERIMENTS. FREDRICK GRIFFITH (1928). Transforming principal of DNA Bacteria are capable of passing genetic information to other bacteria. PHEOBUS LEVENE (1929). Characterized different forms of nucleic acids: DNA and RNA

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DNA

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  1. DNA Unit Two

  2. HISTORICAL DNA EXPERIMENTS

  3. FREDRICK GRIFFITH (1928) • Transforming principal of DNA • Bacteria are capable of passing genetic information to other bacteria

  4. PHEOBUS LEVENE (1929) • Characterized different forms of nucleic acids: DNA and RNA • Determined nucleic acids are made of: adenine (A), thymine (T), cytosine (C), and guanine (G)

  5. OSWALD AVERY (1944) • Determined that DNA is the material in which genes and chromosomes are made.

  6. Hershey-Chase Experiment (1952) • Proteins were not the genetic material, DNA was

  7. ROSALAND FRANKLIN (1951-1953) • Research found picture of DNA • X-ray crystallography • Excluded from large discovery

  8. WATSON AND CRICK (1953) • Discovered the “double helix” structure of DNA • Published paper without mentioning Rosalind Franklin (CONTROVERSY)

  9. ERWIN CHARGAFF (1959) • Discovered three rules about DNA: • # of guanine equals # of cytosine • # of adenine equals # of thymine • # of A, T, C, G varies among species

  10. Backbone (EDGES) • Deoxyribose sugar • Phosphate group

  11. NITROGENOUS BASES (MIDDLE) Guanine Thymine Cytosine Adenine

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