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R epresentation O f S timuli A s N eural A ctivity. ROSANA Project. UCM-UAM-FrI-UPo-UEs. “ Perception ” ⇩ “ Internal Representation ” of the external world. Understand the fundaments of perception. Determine the principles of coding of sensory stimuli.
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RepresentationOfStimuliAsNeuralActivity ROSANA Project UCM-UAM-FrI-UPo-UEs
“Perception”⇩“Internal Representation” of the external world Understand the fundaments of perception Determine the principles of coding of sensory stimuli Interactions sensory inputs - activity of CNS neurons we will be able to reproduce the same spatiotemporal pattern of activity
Lemniscal somatosensory system 500.000 10.000
State of the project (started May 2002) • We set-up a complete electrophysiology lab • We implanted sieve microelectrodes in the peripheral nerve of rats and cats • We obtainedfunctionalregeneration of the sensory nerves • We recorded the electrical activity of the regenerated nerves • We recorded electrical activity simultaneously from the regenerated nerve • and from neurons in the CNS • We developed mathematical and computational models of oscillating neurons • We deveoped specific microstimulators to control the stimulation • We are developing new microstimulators to control the stimulation • We are developing new mathematical and computational models • We are developing new microelectrodes • We are setting-up the 140 simultaneous recording procedure • We are setting-up the new data analysis techniques
D Glomeruli PROJECTION NEURONS R C DENDRITES V Gr Cu
-60 7,5 HZ -30 -64 2 s Amplitud (mV) -50 -68 -70 40 0 Amplitud (mV) -30 -40 Azar 6,0 Hz Amplitud (mV) -30 -80 -50 0 20 40 s 0 10 20 30 -50 -70 -70 s 0 10000 20000 30000
Problems to be solved • If artificial sensors are to be directly connected to the nerve(s), only a very low number of fibers can be interfaced • Interfacing of artificial sensors to a sensory nerve will submit to each axon information concerning different sensory submodalities in an entirely unpredictable fashion