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Gene Regulation

This article explores various mechanisms of gene regulation, including DNA binding proteins, histones, sequence-specific binding, enzyme repression, positive control through activator proteins, and global controls such as catabolite repression and quorum sensing.

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Gene Regulation

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  1. Gene Regulation

  2. DNA Binding Proteins • Histones • Sequence specific • DNA major grove • Homodimeric • Inverted repeats

  3. Enzyme Repression Repressor Corepressor Negative Control of Transcription Operator Operon

  4. Inducer Induction

  5. Positive Control of Transcription • Positive Control • Activator Protein • Inducer - Effector • Operon • Regulon

  6. Two Component Regulation • Signal Transduction • Sensor Kinase • Histidine kinase • Response Regulator • 50 in E. coli

  7. Quorum Sensing • Population density • Autoinducers • Biolumunescence • Virulence • Chemotaxis

  8. Global Controls • Catabolite repression • Glucose effect • Diauxic growth • Catabolite Repressor Protein • cAMP • Stringent Response • Heat shock proteins

  9. Regulation of Bacterial Development • Sporulation • 4 Sigma Factors • Cellular cannibalism • Caulobacter Life cycle

  10. Myxobacteria

  11. RNA-based Regulation • Noncoding RNA • sRNA • 40-400 nucleotides • Antisense RNA • Anti-gene • Riboswitches

  12. Attenuation

  13. Attenuator • Leader Sequence

  14. Regulation of Gene Expression

  15. Gene Expression 2

  16. Gene Expression 3

  17. Gen Expression • Constitutive Enzymes not Regulated • Most Enzymes Can Have Their Activity Regulated • Feedback Inhibition

  18. Other Global Controls • Quorum Sensing • Alternative Sigma Factors • Proteases • Chaperonin

  19. Others Chemotaxis Antisense RNA Triple DNA

  20. Allosteric Sites

  21. Isozymes • Covalent Modification

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