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Synaptic scaling in the developing visual cortex

Synaptic scaling in the developing visual cortex. Niraj S. Desai Brandeis University & The Neurosciences Institute. Cell Cultures Slices Slice Cultures. Neocortical cultures. Use pharmacology to manipulate activity Measure effects on synaptic currents. Quantal currents.

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Synaptic scaling in the developing visual cortex

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  1. Synaptic scaling in the developing visual cortex Niraj S. Desai Brandeis University & The Neurosciences Institute • Cell Cultures • Slices • Slice Cultures

  2. Neocortical cultures Use pharmacology to manipulate activity Measure effects on synaptic currents

  3. Quantal currents

  4. Synaptic scaling • Postsynaptic change in receptor density • Global and multiplicative rescaling • Slow time course (> 12 h)

  5. Dark rearing modifies age effects Control Dark-reared

  6. Monocular deprivation

  7. C D

  8. Channel infection in slice cultures K+ channels: Johns et al. (1999) Burrone et al. (2002)

  9. P16 P23  X L4 X  L2/3 Summary Slow form of homeostatic plasticity Active in visual system development Effects are age- and layer-specific

  10. Acknowledgments Brandeis University Gina Turrigiano Sacha Nelson Robert Cudmore Neurosciences Institute Tanya Casimiro Geoffrey Owens

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