1 / 3

HIV-1 outcompetes HIV-2 in dually infected Senegalese subjects with low CD4 counts

HIV-1 outcompetes HIV-2 in dually infected Senegalese subjects with low CD4 counts. Dana N. Raugi , Geoffrey S. Gottlieb, Papa Salif Sow, Stephen L. Cherne , Macoumba Toure , Fatima Sall , Fatou Traore , Natalie N. Zheng , Ibra N’Doye , Nancy B. Kiviat , Stephen E. Hawes;

yakov
Download Presentation

HIV-1 outcompetes HIV-2 in dually infected Senegalese subjects with low CD4 counts

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. HIV-1 outcompetes HIV-2 in dually infected Senegalese subjects with low CD4 counts Dana N. Raugi, Geoffrey S. Gottlieb, Papa SalifSow, Stephen L. Cherne, MacoumbaToure, Fatima Sall, FatouTraore, Natalie N. Zheng, IbraN’Doye, Nancy B. Kiviat, Stephen E. Hawes; for the University of Washington-Dakar HIV-2 Study Group • Background • Dual infection with HIV-1 and HIV-2 is relatively common in West Africa • Implications for transmission, progression, and antiretroviral therapy are unclear • Very few studies of dual infection exist • Study Aim • To elucidate the relationship between HIV-1 and HIV-2 viral loads among dually infected subjects • Methods • Study population: 65 dually infected (dually seropositive & NAAT+ for HIV-1 and HIV-2) antiretroviral-naïve Senegalese men and women • Quantitative and qualitative testing for HIV-1 and HIV-2 RNA in plasma, oral fluid, cervicovaginal lavage, and semen, and HIV-1 and HIV-2 DNA in PBMC • Cross-sectional methods using baseline viral loads, and generalized estimating equations to account for longitudinal follow-up for some subjects

  2. Results • HIV-1 nucleic acid is more frequently detected and is present at higher levels than HIV-2 at baseline, levels are associated in plasma and PBMC Plasma RNA R=-0.2274 PBMC DNA R=-0.3628

  3. Results, cont. • HIV-1 and HIV-2 plasma RNA and PBMC DNA levels are associated with CD4 count • Conclusions • The difference in HIV-1 and HIV-2 plasma RNA and PBMC DNA levels is correlated with CD4 strata, with HIV-1 levels higher and HIV-2 levels lower at low CD4 strata, compared to the high CD4 stratum • Our data are consistent with the hypothesis that with decreasing CD4 counts and HIV disease progression, HIV-1 generally outcompetes HIV-2 in dually infected subjects • These findings help explain the differences in prevalence and outcome between HIV-1, HIV-2, and HIV-dual infection Plasma RNA PBMC DNA

More Related