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Molecule of the Week ATP Synthase. ...a nanoscale machine. Two molecular motors / generators Enzyme Ion pump. Function: Synthesize ATP / Create proton gradient. ATP – Adenosine triphosphate. Cellular energy „currency“ DNA replication / transcription Cell signalling. ADP + P i → ATP.
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Molecule of the Week ATP Synthase
...a nanoscale machine • Two molecular motors / generators • Enzyme • Ion pump Function:Synthesize ATP /Create proton gradient
ATP – Adenosine triphosphate • Cellular energy „currency“ • DNA replication / transcription • Cell signalling
ATP – Production • Photosynthesis
ATP – Production • Photosynthesis • Aerobic respiration
ATP – Production • Photosynthesis • Aerobic respiration • Anaerobic respiration
Structure determination of F1 • “Structure at 2.8 Å resolution of F1-ATPase from bovine heart mitochondria”,Abrahams, Leslie, Lutter and Walker,Nature Vol. 370, 1994 • Boyer and Walker shared half of the 1997 Nobel Prize in Chemistry
Molecular structure Cell membrane Inside cell organelle Diameter: 9 nm
FO part Ion motor
F1 part Binding change / „Flip-flop“ mechanism
F1 part Binding change / „Flip-flop“ mechanism