Green Chemistry Building HSE Performance into Products

1. Green ChemistryBuilding HSE Performance into Products John KindervaterConsultant, Global Health, Safety, and Environment Partners for Pollution Prevention, 2 December 2009

2. What is Green Chemistry? Green Chemistry The design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances Green Chemistry moves our consideration of how to deal with environmental, health and safety problems from the circumstantial to the intrinsic. 2-December-2009

3. We take a “simple” approach Incremental Improvements • Stay away from the really “bad” stuff • Reduce material use per output (increase efficiency) • Evaluate chemical/chemistry alternatives Step Improvements • Move the state of the art for chemistry • Develop and implement practical alternative reactor technology 2-December-2009

4. Strategic Elements of our Process Review, ID issues, provide input Define Desired State/Establish Expectations Measure Progress, Capture Successes, Take Credit Develop Chemical Process Tools, options, alternatives available – make good decisions Fill the toolbox 2-December-2009

5. Synthetic Route Material Use Comparison 1000 1000 900 900 800 800 700 700 API API 600 600 500 500 bKg bKg 400 400 kg/ kg/ 300 300 200 200 100 100 0 0 ProposedCommercialRoute Early Route Selection Process Def Route Selection Early Process Def TRI Material Use TRI Material Use Water Use Water Use All Other Material Use All Other Material Use TRI TRI - - US EPA Toxic Release Inventory Listed Chemical US EPA Toxic Release Inventory Listed Chemical Example of material efficiency improvement Annual raw material requirements dropped by over 30,000,000 kg due to green chemistry efforts. 2-December-2009

6. Alternative Reactor Technology New process technology such as these coiled tube reactors, being used by members of Lilly's Alternative Reactor Technology (ART) team makes a big impact. Example –Conventional process:154 kg material use/kg out Continuous process: 1.7 kg material use/kg out 2-December-2009

7. Part of the Routine • Green chemistry expectations are built into our development objectives right along with other important criteria such as cost and quality • Development teams are accountable for process efficiency and inherent safety from candidate selection through the development of a manufacturable process • Electronic lab notebooks, used by all chemists, include efficiency, solvent selection, and materials of concern tools to assist chemists in making good decisions when designing synthetic pathways and processes • Progress and determination of “success” is measured and is part of the overall evaluation process which occurs at major development milestones 2-December-2009

8. Conclusions • We already use state of the art chemistry. Improvement means moving the science forward. This is hard, time intensive, and expensive – and worthwhile in reducing material use and safety risks • Internal and partnership resources are active on creative chemistries as well as alternative reactor technologies • We leverage our efforts to improve problem chemistries through active participation in the pre-competitive efforts of collaborative groups, particularly ACS’s Green Chemistry Institute Pharmaceutical Roundtable • Efforts to reduce use of raw materials (such as solvents) in traditional chemistries gives incremental improvements. • Progress at applying alternative reactor technology gives step change in material use and safety. • Inherent safety is aligned with green chemistry progress 2-December-2009

9. Break and Networking – Reconvene at 11:15