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Genetic analysis Susceptibillity genes

SPECIALITY CLINICS FOR DIAGNOSIS AND TREATMENT OF HUMAN PAPILLOMAVIRUS (HPV)-RELATED CUTANEOUS NEOPLASMS SPECIFIC AIMS. Patients with skin tumors (immuno-competent population, transplanted patients, Epidermodisplasia Verruciformis patients, HIV patients).

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Genetic analysis Susceptibillity genes

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  1. SPECIALITY CLINICS FOR DIAGNOSIS AND TREATMENT OF HUMAN PAPILLOMAVIRUS (HPV)-RELATED CUTANEOUS NEOPLASMS SPECIFIC AIMS Patients with skin tumors (immuno-competent population, transplanted patients, Epidermodisplasia Verruciformis patients, HIV patients) Samples collecting for identification of the presence of Papillomavirus infection Blood Biopsy Hair bulbs Cutaneous swab Genetic analysis Susceptibillity genes Molecular and histologic analyses to determine the presence of Papillomavirus infection CHARACTERIZATION OF A STATISTICALLY SIGNIFICANT NUMBER OF PATIENTS IN ORDER TO ESTABLISH PROTOCOLS FOR PREVENTION, DIAGNOSIS AND TREATMENT OF CUTANEOUS NEOPLASMS ASSOCIATED TO HPV INFECTION ISH IHC Genotyping PCR Real Time FISH

  2. ORGANOTYPIC CULTURES Monolayer cultures Siero COMPLEMENTATION OF CLINICAL SERVICES WITH RESEARCH AND DEVELOPMENT ACTIVITIES Development of experimental models in vitro using primary human keratinocytes from healthy donors and patients harbouring HPV infection CELL CULTURES DEVELOPMENT MOLECULAR, CELLULAR AND HISTOLOGIC ANALYSES AIMED TO: IDENTIFY THE MOLECULAR MECHANISMS INVOLVED IN THE CONTROL OF PAPILLOMAVIRUS REPLICATION AND IN THE PROCESS OF HPV-RELATED SKIN TUMORS DEVELOPMENT EVALUATE THE EFFECT OF PHARMACOLOGIC ACTIVE PRINCIPLES INTENDED TO HPV INFECTION WITH ANTINEOPLASTIC PROPERTIES IDENTIFY A “RISK PROFILE” TO SKIN TUMORS BASED ON THE VIRAL GENOTYPING ASSAY

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