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CCK, Satiety, and Associated Disorders

What is CCK?. CCK = CholecystikininPeptide hormoneCauses the Gallbladder (cholecyst) to contract

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CCK, Satiety, and Associated Disorders

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    1. CCK, Satiety, and Associated Disorders Ron Schneider

    2. What is CCK? CCK = Cholecystikinin Peptide hormone Causes the Gallbladder (cholecyst) to contract releasing bile In response to presence of nutrients Pylorus to constrict and inhibits gastric contractions

    3. Nomenclature The term "cholecystokinin" originates from the Latin word chole for "bile and cysto for "sac", and kinin for "move".

    4. History of CCK 1856 Claude Bernard noted that Hydrochloric acid stimulated bile 1903 Wertheimer 1928 Ivy and Oldberg - small intestine hormone 1943 Harper and Raper - Pancreozymin (PZ)

    5. History of CCK 1968 Mutt identified CCK-33 as having maximal cholecystokinetic and panreozymic activity Mutt and Jorpes discovered Pancreozymin (PZ) = CCK

    6. Distribution of CCK Small intestine endocrine l-cells CCK is synthesized in the brain as well

    7. CCK receptors 2 CCK subtype receptors have been discovered Alimentary CCK-A receptor CCK-B Receptor

    8. Structure of CCK

    9. Digestive system

    10. Effects of CCK

    11. Animal studies Animal studies have further illustrated the importance of CCK and its binding sites

    12. OLETF: A CCK knockout Rodent Otsuka Long Evans Tokushima Fatty rats (OLETF) Insensitive to the feeding inhibitory actions of peripherally injected CCK-A Meal size Differs

    13. Gastrectomized Humans No difference in desire before or after meals as compared to controls Ate same amount of food But no increase in satiety

    14. Clinical aspects of CCK CCK is not only a gut peptide utilized in satiation, it can be useful in treating several disorders/illnesses such as eating disorders, enzymatic diseases as well as ways to better our general health

    15. Diagnostic uses CCK and the Gall bladder Secretin-CCK test Acalulous biliary disease Cystic duct syndrome Celiac disease Pentagastrin test

    16. Therapeutic uses CCK and its role in paralytic ileus Though more controlled studies are needed to determine its efficacy

    17. Abnormal expression of CCK CCK Assays Little in known about CCK in a diseased state New and research indicated CCK as playing an important role in certain disorders

    18. DSM-IV: Bulimia Nervosa A. Recurrent episodes of binge eating. B. Recurrent inappropriate compensatory behavior in order to prevent weight gain C. . The binge eating and inappropriate compensatory behaviors D. Self-evaluation E. The disturbance does not occur exclusively during episodes of Anorexia Nervosa

    19. CCK and Bulimia Very little research until the last 10 years CCK-8

    20. CCK and Bulimia

    21. DSM-IV: Anorexia Nervosa 1) Refusal to maintain body weight 2) intense fear of gaining weight or becoming fat 3) disturbance in the way in one's body weight, size, or shape is experienced

    22. CCK and Anorexia Little in know about the role of CCK and anorexia Dysfunctional satiety

    23. Other disorders Huntington's Disease Parkinsons disease

    24. Anxiety and CCK Extensive studies on CCK and anxiety/panic attacks have been carried out in the past few years CCK4 and Pentagastrin CI-988 CCK-B antagonists

    25. CCK, Panic and Pentagastrin Pentagastrin is a potent CCK agonist and can cause panic attacks even in those who do not suffer from them

    26. Pentagastrin

    27. Final note on Schizophrenia CCK may play a role in schizophrenia CCK levels in CSF Deficits in CCK-related neurons in the limbic system associated with schizophrenia

    28. Conclusion CCK is involved with many systems in the body Satiety Anxiety Panic Pathology of CCK diagnostics

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