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Testing a Mechanism: Kinetic Isotope Effects

Testing a Mechanism: Kinetic Isotope Effects. Primary Isotope Effect - rate change due to isotopic substitution at a site of bond breaking or bond making in the rate determining step of a mechanism.

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Testing a Mechanism: Kinetic Isotope Effects

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  1. Testing a Mechanism: Kinetic Isotope Effects • Primary Isotope Effect - rate change due to isotopic substitution at a site of bond breaking or bond making in the rate determining step of a mechanism. • Secondary Isotope Effect - rate change due to isotopic substitution at other than a site of bond breaking or bond making in the rate determining step of a mechanism.

  2. Primary Kinetic Isotope Effect:Typical Values

  3. Examples of Kinetic Isotope Effects

  4. More Examples of Kinetic Isotope Effects

  5. Secondary Kinetic Isotope Effects • Differences in steric demand • Hyperconjugative effects • Differences in inductive effect

  6. Examples of Secondary Kinetic Isotope Effects Differences in Steric demand

  7. Secondary Kinetic Isotope Effects

  8. Secondary Kinetic Isotope Effects Hyperconjugative effects

  9. Secondary Kinetic Isotope Effects Inductive effects

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