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Time (Hours)

B. ABCA1. ABCG1. A. 40. 10. *. *. 7. 9. 35. ABCA1. 8. 6. 30. *. ABCG1. 7. *. 5. *. Fold Induction. Fold Induction. *. 25. 6. *. *. Fold Induction. 4. *. 20. 5. *. *. 4. 3. 15. 3. 10. 2. 2. 5. 1. 1. 0. 0. T0. GW. 623. VEH. VEH. 0. VEH.

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Time (Hours)

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  1. B ABCA1 ABCG1 A 40 10 * * 7 9 35 ABCA1 8 6 30 * ABCG1 7 * 5 * Fold Induction Fold Induction * 25 6 * * Fold Induction 4 * 20 5 * * 4 3 15 3 10 2 2 5 1 1 0 0 T0 GW 623 VEH VEH 0 VEH 623 C ABCA1 ABCG1 9 14 5 8 12 T0 GW 623 4 7 10 6 Plasma LXR-623 (uM) 3 Fold Induction Fold Induction 8 5 4 6 2 3 4 2 1 2 1 0 0 0 0 2 4 6 8 0 2 4 6 8 0 2 4 6 8 D Time (Hours) Time (Hours) Time (Hours) ABCA1 ABCG1 14 5 EC50 = 0.23 12 EC50 = 0.23 4 10 3 8 Fold Induction Fold Induction 6 2 4 1 2 0 0 0.0 1.0 2.0 3.0 0.0 1.0 2.0 3.0 ABCA1 ABCG1 Plasma GW3965 (uM) Plasma GW3965 (uM) E 14 5 EC50 = 0.42 12 EC50 = 0.42 4 10 3 8 Fold Induction Fold Induction 6 2 4 1 2 0 0 0.0 5.0 10.0 0.0 5.0 10.0 Plasma LXR-623 (uM) Plasma LXR-623 (uM)

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