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CM-Path.Network: Supporting Pathology Research and Clinical Trials

Discover how CM-Path.Network is addressing the decline in clinical academic pathologists, supporting molecular testing, and fostering collaboration between pathology research, clinical practice, and industry.

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CM-Path.Network: Supporting Pathology Research and Clinical Trials

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  1. CM-Path Network Development +

  2. What is CM-Path? • Severe decline in the number of clinical academic pathologists over the past 15 years compared with other clinical academic specialties • Increasing need for molecular testing within the NHS • - New technologies • - New skills required • - Pathology capacity • Disconnect between pathology research, clinical practice and industry

  3. What is CM-Path? Karin Oien (Chair), Andy Hall (Deputy Chair) Input from trial designers and funders Input from patients and public CM-Path Executive Group Skills and capacity Clinical trials Discovery Technology and information Clare Verrill Gareth Thomas AbeerShaaban Louise Jones Cross-cutting themes Biosample Consent Engaging with wider initiatives Supporting Trainees Patient and Public Engagement

  4. CM-Path Vision: Working Together Pathology research across NHS, academia and industry Supporting clinical trials and tissue-based research Coordinating new approaches to diagnosis

  5. CM-Path Vision: Working Together CRUK Accelerators CRUK Strat Med CCB/UKCRC NC3R Academic training Molecular pathology MRC Nodes CM-Path Biobanking Technology & innovation Clinical Trials RCPath Sanger Institute Biomarker Research NCRI CSGs PathSoc Genomics England

  6. CM-Path Network Network • The ambition: • A UK-wide network of CM-Path ‘badged’ pathology centres • The purpose/objectives: • Help establish UK-wide best practice for molecular testing across the UK • Support pathology centres to engage in research-based activities: biobanking, clinical trials, tissue-based research • Support academic training and development

  7. Salto-Tellez M. Clinical Chemistry 2007 Jul;53(7):1188-90 Anatomical clinical-molecular dimension of pathology Molecular Pathology (Molecular Diagnostics) Clinical Medicine Traditional Pathology The future of modern medicine will be dictated by technical advancement, management advancements, and advancements in molecular medicine – stratified medicine 2. Molecular Diagnostics in the fastest growing area in modern medicine

  8. Changing the way we handle human tissues • Optimal fixation for immunohistochemistry • Routine handling of fresh tissue • Optimal tissue selection for molecular analysis • Better regional/ national standardisation • Biobanking– a focus on tissue quality • Engagement with industrial partners

  9. 100,000 Genomes Project • Handling the tissues • WGS - formalin fragments the DNA • Eliminating formalin from theatres • Small diagnostic biopsies best in 10% NBF • Training staff to sample fresh tissue • Fresh tissue can be stored at 4oC for ? * • Maintenance at 4oC during transport • Recording time of removal and arrival • Transformational project • Rare genetic diseases • Cancer samples • Fresh samples 5 x 5 x 5mm • Cellularity score (EQA) • Consent by Genomic staff • HRA/HTA statement April 2017 * Currently under discussion

  10. CM-Path Network: An Inclusive Network Network • CM-Path Network Requirements • Named CM-Path representative in each department • Best practice guidelines for molecular testing • SOPs for tissue processing re genomics (fixation times etc.) • Judging tumour content/quality • Pathway for frozen tissue analysis/collection • CM-Path Network Aspirations • Research/ training activities • SOP for releasing tissues for research • Accessing diagnostic archives for research – creating research biobanks • Training/research opportunities – workshops, meetings, grants, directory

  11. What will you get for signing up to the CM-Path Network Network • Add your name to the pathology directory – become involved in research • contact departments/fellow pathologists for advice • Advice on obtaining research funding • Check out information on training courses, workshops, funding opportunities and more • See case studies from fellow pathologists • Check out our academic roadmap and advice on training • Download and utilise our SOPs for best practice guidelines for molecular testing, tissue processing re genomics (fixation times etc.), judging tumour content/quality, pathway for frozen tissue analysis/collection • Routinely updated SOPs based on changes in pathology practice • Quarterly newsletter – linking you to CM-Path activity, opinion pieces, workshops, training, opportunities to input into calls for information • Opportunity to advertise specific projects

  12. CM-Pathologists (The Pathology Directory) Network • I'm a pathologist, what will I get out of being on the directory • Tell us your name, email, area of interest, what you might be interested in getting involved in an we can match you up to various opportunities/you may be contacted by various people to get involved with projects or scientific review committees • Easily link up with fellow pathologists interested in research or trainees looking for projects to get involved in • I'm a research funding organisation what will I get out of using the directory: • CM-Path encourages funding organisations that award research grants to incorporate a pathology review • The pathology directory will help you to identify pathologists across the country that might be interested in joining a funding committee. You will be able to see their speciality and any previous experience they might have • I'm part of an industrial organisation or a researcher what will I get out of using the directory: • Want to involve a pathologist in your work or need help developing a research proposal, use the directory to more easily link yourself up to pathologists who want to be involved in research.

  13. CM-Path Network – More ideas? Network • In the future what you will be able to access through the Network • Cost recovery tool for tissue • Contracts • Business cases • Links to CCB and CM-Path biobank network • Case studies from pathologists involved in research • Do you have any other ideas you would like to see on the CM-Path Network – please get in touch by emailing helen.pitman@ncri.org.uk

  14. The Alternative https://goo.gl/images/wh434K https://goo.gl/images/bRlhmX

  15. Find out more about what CM-Path is doing… cmpath.ncri.org.uk Email cmpath@ncri.org.uk for… Pathology collaborations Pathology advice Further information

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