1 / 5

Fragile X Syndrome

Fragile X Syndrome. Kathryn Clark Tanya Tyler Divya Trehan Shalini Kochicheril. PEDIGREE FOR FRAGILE X SYNDROME. MODES OF INHERITENCE. Dominant Sex-Linked More dominant in males Only one copy of X chromosome 1 in 4000 males 1 in 8000 females. MAIN SYMPTOMS. Learning disabilities

zephr-flowers
Download Presentation

Fragile X Syndrome

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Fragile X Syndrome Kathryn Clark Tanya Tyler Divya Trehan Shalini Kochicheril

  2. PEDIGREE FOR FRAGILE X SYNDROME

  3. MODES OF INHERITENCE • Dominant Sex-Linked • More dominant in males • Only one copy of X chromosome • 1 in 4000 males • 1 in 8000 females

  4. MAIN SYMPTOMS • Learning disabilities • Behavioral problems (such as hyperactivity, and autistic tendencies) • Physical characteristics (such as long face, protruding ears, lax joints and enlarged testes in males)

  5. Chromosomal Location • Mutation of FMR-I gene on X chromosome (chromosome locus Xq27) • Variable number of CGG trinucleotide repeats • Normal repeats are between 5 and 50 • Affected individuals typically have more than 200 • Fragile X syndrome is a trinucleotide repeat disorder that demonstrates anticipation.

More Related