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Kuala Lumpur, J uly 2nd 2013

Kuala Lumpur, J uly 2nd 2013. The ANRS International VISCONTI Post Treatment Controller Cohort. OBJECTIVES. To build an international cohort of Post Treatment Controllers in order to : Uncover mechanisms underlying viral control, i.e. HIV remission

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Kuala Lumpur, J uly 2nd 2013

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  1. Kuala Lumpur, July 2nd 2013 The ANRS International VISCONTI Post Treatment Controller Cohort

  2. OBJECTIVES • To build an international cohort of Post Treatment Controllers in order to : • Uncover mechanisms underlying viral control, i.e. HIV remission • Identify predictive markers associated with viral control after treatment interruption • Main Outcome: To identify patients in whom HAART could be safely interrupted

  3. To increase the number of cases: • To describe epidemiological and clinical characteristics of PTC • Age, sex, PHI, Time of treatment initiation, treatment duration, ARV combinations used, transmission group… • To describe Virological and Immunological characteristics • Analyse and quantification of the cellular and anatomical reservoirs • Viral properties and interactions between viral and cellular proteins • Innate and adaptive immunity, antibody response…. • To Compare to other cohortsof patients at different stages of HIV infection: PHI, HIV controllers, Chronic patients, patients on HAART…

  4. Methodology • Inclusion criteria • Treatment initiation with VL >2000 HIV-RNA copies/ml, whatever the timing of infection • Treatment for more than 12 months • Viral control after Treatment interruption below 400 copies/ml for at least 12 months • Data collected once a year

  5. General organisation • Funded and organized : ANRS • International Steering Committee • International Scientific Committee • PI : AsierSaez-Cirionand Laurent Hocqueloux • International recruitment: Two levels of inclusion 1 – with Clinical and epidemiological data 2 – with Clinical and epidemiological data + BIOBANK CONTACT : visconti@anrs.fr

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