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Saline

Binge cocaine treatment / Withdrawal day 1 / D1R . Saline. Cocaine. NS. counts /min. 600. 500. 400. CPu. 300. 200. Nac. 100. 0. Saline. Cocaine. NS. counts /min. 1000. 800. 600. 400.

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Saline

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  1. Bingecocainetreatment / Withdrawalday 1 / D1R Saline Cocaine NS counts/min 600 500 400 CPu 300 200 Nac 100 0 Saline Cocaine NS counts/min 1000 800 600 400 Supplemental Figure 1: Computer-enhanced autoradiograms of coronal brain sections from saline or cocaine-treated mice showing different region of interest. Brain sections were incubated with [3H]-SCH23390 as described in material and methods and radioactivity was detected using beta imager. (CPu, caudate putamen; Nac, nucleus accumbens; SN, substantianigra; VTA, ventral tegmental area; NS: non specific binding) 200 SN 0 VTA

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