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Bose. - Cyclin-dependent Kinase Inhibitor Proteins - Regulation of CDK-cyclins activity - Cell cycle checkpoints. Stewart. - characteristics of tumor cells and the corresponding therapeutic targets - “old” stroma and cancer-associated fibroblasts - telomeres/maintenance of telomeres
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Bose • - Cyclin-dependent Kinase Inhibitor Proteins • - Regulation of CDK-cyclins activity • - Cell cycle checkpoints
Stewart • - characteristics of tumor cells and the corresponding therapeutic targets • - “old” stroma and cancer-associated fibroblasts • - telomeres/maintenance of telomeres • - effectors of cellular senescence
Huettner • - What is transdifferentiation? How is it accomplished? • - What are the types of ES cells? What is meant by naïve vs primed ES cells? • - What are the types of potency? • - What are the different classifications of stem cells?
Weber • - Characteristics and differences between proto-oncogenes and tumor suppressors • - how is translation altered in cancer cells? Ex: micro RNAs and translation