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Cellular Respiration Part 4

Cellular Respiration Part 4. Oxidative Phosphorylation Pages 98 to 100. Oxidative Phosphorylation. Location Cristae of mitochondria Final Acceptor of Electrons Oxygen. Fig. 9-13. NADH. 50. Electrons are transferred from NADH or FADH 2 to the electron transport chain

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Cellular Respiration Part 4

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  1. Cellular Respiration Part 4 Oxidative Phosphorylation Pages 98 to 100

  2. Oxidative Phosphorylation • Location • Cristae of mitochondria • Final Acceptor of Electrons • Oxygen

  3. Fig. 9-13 NADH 50 Electrons are transferred from NADH or FADH2 to the electron transport chain Electrons are passed through a number of proteins to O2 The electron transport chain generates no ATP The chain’s function is to break the large free-energy drop from food to O2 into smaller steps that release energy in manageable amounts e– 2 NAD+ FADH2 FAD Multiprotein complexes e– 2  FAD 40 FMN  Fe•S Fe•S Q  Cyt b Fe•S 30 Cyt c1 IV Free energy (G) relative to O2 (kcal/mol) Cyt c Cyt a Cyt a3 20 e– 2 10 (from NADH or FADH2) 2 H+ + 1/2 O2 0 H2O

  4. Electron transfer in the electron transport chain causes proteins to pump H+ from the mitochondrial matrix to the intermembrane space Intermembrane space becomes positively charged; the matrix because negatively charged – concentration gradient is established = potential energy

  5. Fig. 9-14 INTERMEMBRANE SPACE H+ As H+ escapes from positively charged intermembrane space through ATP Synthaseto the negatively charged matrix, ATP synthase spins using energy released from H+ going down its concentration gradient to phosphorylate ADP making ATP Chemiosmosis is using energy of a H+ gradient to do cellular work Stator Rotor Internal rod Catalytic knob ADP + ATP P i MITOCHONDRIAL MATRIX

  6. NADH makes 3 ATP; FADH2 makes 2 ATP ATP Yield from 1 glucose

  7. Certain Poisons Interrupt Events in Cellular Respiration

  8. 3 Categories of Poison • ETC Inhibitors • Rotenone Blocks ETC at 1st protein complex • Cyanide and CO2 block ETC at 3rd protein complex • RESULT = no H+gradientno ATP • ATP synthase Inhibitors • Oligiomycin • Keep H+ from passing through ATP synthase • RESULT = no chemiosmosis

  9. 3 Categories of Poison • Uncouplers • Make the membrane of the mitochondria “leaky” to H+ • Dintrophenol (DNP) unsuccessfully used for weight loss • RESULT – Can’t establish H+ gradeint no ATP

  10. Benefit of poisons… • Pesticides • Antibodies • Help to understand the biochemistry of cellular respiration

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