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Beckman Coulter - Capillary Electrophoresis Products

From the high-resolution applications of PA 800 plus to CESI 8000 Separation-ESI Module, Beckman enhances CE technologies to optimize your workflow efficiency. This presentation provides various applications of Capillary Electrophoresis along with details on CESI 8000

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Beckman Coulter - Capillary Electrophoresis Products

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  1. Capillary Electrophoresis Products By Beckman Coulter

  2. About Capillary Electrophoresis Capillary Electrophoresis (CE) is a procedure in which ionic species of molecules are separated by their charge, frictional forces and hydrodynamic radius

  3. Applications of CE • CE is used extensively in diagnostic and clinical sciences • It is popular with scientists, physicians and law enforcement officials • It is used in analysis of pharmaceuticals • It is used in genetic analysis • It is used in carbohydrate analysis for the determination of post translational modifications

  4. Applications of CE • It is used in protein characterization • It is used in counter-ion analysis in drug discovery • It is used in pharmaceuticals with chiralcenters • It is used in glycan analysis • It is used in therapeutic protein characterization

  5. Beckman Coulter CE Products • Providing quality CE products for over a decade, Beckman Coulter now introduces CESI 8000 High Performance Separation instrument • It is an ESI Module with OptiMS technology • It also has the first commercial CESI sprayer combined with new CE instrumentation specifically designed for mass spectrometry (MS) • CESI 8000 is ideal for identifying minute polar and charged analytes such as drugs, drug metabolites, organic acids, amino acids, etc.

  6. Benefits of CESI 8000 • Quality Control: CESI allows usage of higher conductivity buffers and larger I.D. capillaries, so it enables: • Flexibility in sample load • Ability to create better separation efficiencies • Use of higher ionic strength buffers • Automated Sample Introduction : • Accommodates 96-well plates of 0.5 to 2 mL auto sampler vials • Reduces bottlenecks in sample handling • Increases system capacity

  7. Benefits of CESI 8000 • Multiple Separation Modes: • Works with Voltage, Current, Power, Pressure and Vacuum • Programming of both step and linear gradients • Simultaneous application of pressure or vacuum on both ends of the capillary • Compatible with various electrophoresis methods • UV Detector Sensitivity: Selectable Wavelength UV Detector of up to seven filters in an assembly, allowing wavelength changes during a run • Essential for small mass loads and small detection path lengths • Regulated environment helps "lock-down" a method of separation • Complete fiber-optic technology to lower the noise on the detection system

  8. Benefits of CESI 8000 • Specialized CE Calculations: • Apparent mobility, mobility, corrected peak area, molecular weight and iso-electric point calculations possible • System suitability to use for decision making • Sample Tray Temperature Control: • Allows temperature maintenance of sample from 4 to 60 degree Celsius • Thus, minimizing the degradation of temperature-labile compounds and controlling reaction rates when enzyme kinetics • Diode-Array Detection: • High resolution spectral scanning without compromising resolution • Allows library to search algorithms to accurately identify a compound • Four channels of data can be viewed, collected and analyzed in real-time

  9. Visit https://www.beckmancoulter.com/to learn more about CESI 8000

  10. Thank You

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