1 / 6

DNA Methyltransferase Screening

https://www.creative-biogene.com/Services/Drug-Discovery-Services/DNA-Methyltransferase-Screening-and-Profiling.html<br>

GeorgeBennie
Download Presentation

DNA Methyltransferase Screening

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. DNA Methyltransferase Screening Creative Biogene offers DNMTs assays, including DNMT1, DNMT3A and DNMT3B, which will be performed by Chemiluminescent or radiolabeled method. A methyl group from S-adenosyl-methionine (SAM) is transferred to the C5 position of the pyrimidine ring of cytosine residues by DNMTs in genomic CpG dinucleotides. CpG dinucleotides are preferentially located in particular regions in the genome, including clusters in gene promoters called CpG islands. CpG methylation plays a critical role in several aspects, inlcuding silencing retrotransposon element sequences (i.e., LINE-1 or Alu repeats), imprinting, X chromosome inactivation, regulating gene expression, and cellular transformation (Jason, et al. 2013).

  2. Process of DNA methylation A family of enzymes, DNA methyltransferases (DNMTs) carry out the addition of methyl group. Five DNMT isoforms, DNMT1, DNMT2, DNMT3a, DNMT3b, and DNMT3L are in genomic, however only three DNMTs (DNMT1, DNMT3A, and DNMT3B) are involved in the establishment and maintenance of DNA methylation patterns.

  3. Advantages of DNMTs screening . Inhibitors/activators screening with more than 3 assays . IC50 determination and single point concentration assays . Fast turnaround time . High quality data results

  4. Contact information Provider: Creative Biogene URL:https://www.creative-biogene.com/Services/Drug-Discovery-Services/DNA-Methyltransferase-Screening-and-Profiling.html Address: 45-1 Ramsey Road, Shirley, NY 11967, USA Phone No. 1-631-619-7922

More Related