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DNA Methyltransferase Screening

The process of DNA methylation is controlled at several different levels in normal and diseased cells. A family of enzymes, DNA methyltransferases (DNMTs) carry out the addition of methyl group.<br><br>https://www.creative-biogene.com/Services/Drug-Discovery-Services/DNA-Methyltransferase-Screening-and-Profiling.html

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DNA Methyltransferase Screening

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  1. DNA Methyltransferase Screening Creative Biogene offers DNMTs assays, including DNMT1, DNMT3A and DNMT3B, which will be performed by Chemiluminescent or radiolabeled method. A methyl group from S-adenosyl-methionine (SAM) is transferred to the C5 position of the pyrimidine ring of cytosine residues by DNMTs in genomic CpG dinucleotides. CpG dinucleotides are preferentially located in particular regions in the genome, including clusters in gene promoters called CpG islands. CpG methylation plays a critical role in several aspects, inlcuding silencing retrotransposon element sequences (i.e., LINE-1 or Alu repeats), imprinting, X chromosome inactivation, regulating gene expression, and cellular transformation (Jason, et al. 2013).

  2. Process of DNA methylation A family of enzymes, DNA methyltransferases (DNMTs) carry out the addition of methyl group. Five DNMT isoforms, DNMT1, DNMT2, DNMT3a, DNMT3b, and DNMT3L are in genomic, however only three DNMTs (DNMT1, DNMT3A, and DNMT3B) are involved in the establishment and maintenance of DNA methylation patterns.

  3. Advantages of DNMTs screening . Inhibitors/activators screening with more than 3 assays . IC50 determination and single point concentration assays . Fast turnaround time . High quality data results

  4. Contact information Provider: Creative Biogene URL:https://www.creative-biogene.com/Services/Drug-Discovery-Services/DNA-Methyltransferase-Screening-and-Profiling.html Address: 45-1 Ramsey Road, Shirley, NY 11967, USA Phone No. 1-631-619-7922

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