CBET Overview

1. CBET Overview National Science Foundation Chemical, Bioengineering, Environmental and Transport Systems Division Judy Raper

2. Outline • CBET Organizational Structure • CBET FY 2007 Budget Request • Statistics • CBET Priority Areas • Funding Opportunities • Typical Projects

3. CBET’s Role • Division of Chemical, Bioengineering, Environmental, & Transport Systems (CBET) • Merger of CTS & BES on October 1, 2006 • Support Research in Chemical, Bioengineering, Environmental, & Transport Systems • Catalyze the merging of biology, chemistry, physics and socio-economic science in engineering research • Support research to enhance and protect US national health, energy, environment, security and wealth

4. Division Director Judy Raper Senior Advisor Marshall Lih Deputy Division Director Bob Wellek Chemical, Biochemical, and Biotechnology Systems Transport and Thermal Fluids Biomedical Engineering and Engineering Healthcare Environmental Engineering and Sustainability Process and Reaction Engineering Maria Burka Thermal Transport Processes Pat Phelan Research to Aid Persons With Disabilities Bob Jaeger Environmental Engineering Pat Brezonik Catalysis and Biocatalysis John Regalbuto Interfacial Processes And Thermodynamics Bob Wellek Biomedical Engineering Semahat Demir Environmental Technology Cindy Ekstein Biochemical Engineering Bruce Hamilton Particulate and Multiphase Processes Vacant Biophotonics Leon Esterowitz Energy for Sustainability Vacant Biotechnology Fred Heineken Fluid Dynamics Bill Schultz Environmental Sustainability Cindy Lee Chemical and Biological Separations Geoff Prentice Combustion, Fire, and Plasma Systems Phil Westmoreland CBET Organizational Chart

5. CBET Budget • FY 2006 Plan • BES $52 million • CTS $71 million • FY 2007 Request • CBET $124 million

6. CBET Proposals and Awards FY 04-06

7. CBET CAREER Success Rates – FY 04-06

8. 1179 – Environmental Technology 1401 – Catalysis and Biocatalysis 1402 – Biochemical Engineering 1403 – Process and Reaction Engineering 1406 – Thermal Transport Processes 1407 – Combustion, Fire, and Plasma Systems 1414 – Interfacial Processes and Thermodynamics 1415 – Particulate and Multiphase Processes 1417 – Chemical and Biological Separations 1440 – Environmental Engineering 1443 – Fluid Dynamics 1491 -- Biotechnology 5342 – Research to Aid Persons with Disabilities 5345 – Biomedical Engineering 7236 – Biophotonics 7643 – Environmental Sustainability 7644 – Energy Sustainability CBET 2006 Success Rates 1179 1401 1402 1403 1406 1407 1414 1415 1417 1440 1443 1491 5342 5345 7236

9. 1179 – Environmental Technology 1401 – Catalysis and Biocatalysis 1402 – Biochemical Engineering 1403 – Process and Reaction Engineering 1406 – Thermal Transport Processes 1407 – Combustion, Fire, and Plasma Systems 1414 – Interfacial Processes and Thermodynamics 1415 – Particulate and Multiphase Processes 1417 – Chemical and Biological Separations 1440 – Environmental Engineering 1443 – Fluid Dynamics 1491 -- Biotechnology 5342 – Research to Aid Persons with Disabilities 5345 – Biomedical Engineering 7236 – Biophotonics 7643 – Environmental Sustainability 7644 – Energy Sustainability Percentage of Average Awarded vs Average Requested - FY 04 1179 1401 1402 1403 1406 1407 1414 1415 1417 1440 1443 1491 5342 5345 7236

10. 1179 – Environmental Technology 1401 – Catalysis and Biocatalysis 1402 – Biochemical Engineering 1403 – Process and Reaction Engineering 1406 – Thermal Transport Processes 1407 – Combustion, Fire, and Plasma Systems 1414 – Interfacial Processes and Thermodynamics 1415 – Particulate and Multiphase Processes 1417 – Chemical and Biological Separations 1440 – Environmental Engineering 1443 – Fluid Dynamics 1491 - Biotechnology 5342 – Research to Aid Persons with Disabilities 5345 – Biomedical Engineering 7236 – Biophotonics 7643 – Environmental Sustainability 7644 – Energy Sustainability CBET Unsolicited Proposals FY 07 as of 10-20-06 1179 1401 1402 1403 1406 1407 1414 1415 1417 1440 1443 1491 5342 5345 7236

11. CBET’s 2007 Budget By Program 1179 – Environmental Technology 1401 – Catalysis and Biocatalysis 1402 – Biochemical Engineering 1403 – Process and Reaction Engineering 1406 – Thermal Transport Processes 1407 – Combustion, Fire, and Plasma Systems 1414 – Interfacial Processes and Thermodynamics 1415 – Particulate and Multiphase Processes 1417 – Chemical and Biological Separations 1440 – Environmental Engineering 1443 – Fluid Dynamics 1491 -- Biotechnology 5342 – Research to Aid Persons with Disabilities 5345 – Biomedical Engineering 7236 – Biophotonics 7643 – Environmental Sustainability 7644 – Energy Sustainability 1179 1401 1402 1403 1406 1407 1414 1415 1417 1440 1443 1491 5342 5345 7236 7243 7244

12. CBET Priority AreasFY07 • Nanoscale Science & Engineering • Cyberinfrastructure (CI) • Energy, Environment & Sustainability • Biology in Engineering • Multi-scale Modelling

13. CBET CAREER Success Rates FY 06 1401 1402 1403 1417 1491 1406 1407 1414 1415 1443 5342 5345 7236 1440 1179 Chemical, Biochemical, & Biotechnology Systems Transport & Thermal Fluids Phenomena Biomedical Engineering & Engineering Healthcare Environmental Engineering & Sustainability

14. CBET CAREER Proposals Received FY 07 1401 1402 1403 1417 1491 1406 1407 1414 1415 1443 5342 5345 7236 1440 1179 Chemical, Biochemical, & Biotechnology Systems Transport & Thermal Fluids Phenomena Biomedical Engineering & Engineering Healthcare Environmental Engineering & Sustainability

15. CBET Funding Opportunities • NNI (National Nanotechnology Initiative) • $29 Million for NIRT and NER • $22 Million for CBET core • Sensors/Explosives • $5 Million • EFRI (Emerging Frontiers in Research & Innovation) • Support for Interdisciplinary Group Projects • $25 Million Total for ENG • CYBERINFRASTRUCTURE for RECONFIGURABLE SYSTEMS • CELLULAR-MOLECULAR BIOENGINEERING

16. NNI Emphasis in FY 2007  Reduced budget for NIRT and NER offset by increases in core nano awards  Increased investments will be dedicated to research and education on:  Complex large nanosystems including research on nanoscale devices and system architecture, dynamic and emerging behavior, and fabrication  Three-dimensional measurements of domains of engineering relevance  Converging science, engineering and technology from the nanoscale, by integrating nanosystems into applications in manufacturing, information systems, medicine, environment, etc.

17. NNI Emphasis in FY 2007 (Continued)  Increased investments will be dedicated to research and education on:  Joint research programs addressing potential implications of nanotechnology with other federal agencies (NIOSH, EPA FDA, USDA and NIST)  Earlier educational programs and teaching materials, including for K-12, with access to NSF educational networks (NUE, NISE, NNIN)  Partnerships of academic researchers with industry, medical facilities and states through Grant Opportunities for Academic Liaison with Industry (GOALI) and Partnerships for Innovation (PFI) programs

18. 10-20 Year Vision  1st Generation:Passive nanostructures~2000 E.g., coatings, nanoparticles, nanostructured metals, polymers, ceramics  2nd Generation:Active nanostructures~2005 E.g., transistors, amplifiers, targeted drugs, actuators, adaptive structures  3rd Generation: Systems of nanosystems~2010 E.g., guided molecular assembling; 3D networking and new system architectures, robotics  4th Generation: Molecular nanosystems~2020 E.g., molecules as devices/components ‘by design’, based on atomic design, hierarchical emerging functions, evolutionary systems Increased integration, system approach Converging science and engineering AIChE Journal, 2004, Vol. 50 (5), MC Roco

19. Faculty Early Career Development Program(CAREER) CAREER Eligibility Applicants Must:  Hold a doctoral degreeas of submission date  Be untenured as of submission date Be employed in a tenure-track(or equivalent) position as of October 1 following submission  Be employed as an assistant professor (or equivalent) as of October 1 following submission  Have not competed more than two times previously in the CAREER program Have not previously received an NSF CAREER or PECASE award

20. Award Criteria Intellectual merit • Importance in advancing understandingin a field • Creativity and novelty of approach • Qualifications of investigators • Completeness of research plan • Access to resources Broader impacts • Promotion of teaching and training • Inclusion of underrepresented minorities • Enhancement of infrastructure & partnerships • Dissemination of results • Benefits to society

21. TYPICAL PROJECTSChemical, Biochemical and Biotechnology Systems A Synthetic Delivery Vehicle for Gene Transfer - “hitchhike” gene delivery nanoparticles onto motor protein complexes - convert chemical energy to mechanical work - carry nanoparticle cargo toward cell nuclei Suzie Pun, U. of Washington • Bloodless Biosensing • with Carbon Nanotubes • - implantable capillary devices • filled with carbon nanotubes • monitor glucose levels • without drawing blood • for diabetes and other biosensors Michael Strano, UIUC

22. TYPICAL PROJECTSTransport and Thermal Fluids Phenomena High-Fidelity Numerical Modeling & Simulation of Fire Suppression • predicts multiphase turbulent mixing processes over a wide range of time/length scales. • grand challenge of turbulence modeling with reactions • multi-scale modeling on both large and small scales • includes Sandia, Navy & NIST interactions plus excellent educational components. Paul E. DesJardin, SUNY Buffalo • Nanocolloid Assembly and Dispersion by Quantum “Design” of van der Waals Forces • nanocolloids have remarkable electrical, optical and • reactive propoerties • need to prevent aggregation by predicting and • controlling van der Waals forces • use solvent mixtures to “shield” nanocolloids to keep • them stable Stable Nanoparticles (groups of red atoms) with co-solvent “shield” (blue) Darrell Velegol & Milton W. Cole, Penn State Unstable (aggregated) particles

23. TYPICAL PROJECTSBiomedical Engineering and Engineering Healthcare B’Quest Crew Michael Lambert, SDSU - completed 2,500 mile Transpac Yacht Race - each crew member except the skipper had a disability - Engineering students at San Diego State University designed adaptive equipment on the yacht for crew members with disabilities 50 mm 5 mm Biomimetic Bone -mimic both composition and nanostructure of bone - prepare synthetic bone prosthetics - load- bearing - bioresorbable - enable regeneration of hard tissue prosthetics into natural bone. NIRT: Laurie Gower (UF), Elliot Douglas (UF), John Mecholsky (UF), Barbara Boyan (GTI)

24. TYPICAL PROJECTSEnvironmental Engineering & Sustainability An Autonomous Microbial Genosensor for Freshwater Microbial Ecology - remote sampling - high frequency and high degree of specificity - multi-day deployment in lakes to detect bacteria David Fries, Wisconsin • Aquatic Nano Environmental Heath and Safety of Nanomaterials and Their Bimolecular Derivatives • - binding of lysophospholipid onto single-walled carbon nanotubes (SWNTs) • over a silicon substrate • finalist at the Science & Engineering Visualization Challenge 2006 • by NSF and the Science magazine. Pu Chun Ke Clemson University

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