1 / 14

Tumor Marker Detection

Creative Biolabs provides a comprehensive range of recombinant antibodies of the key tumor for research processes and diagnostic assay developments for our clients.<br>https://www.antibody-creativebiolabs.com/category-introduction/tumor-marker-detection-1.htm

Shaw2
Download Presentation

Tumor Marker Detection

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Tumor Markers in Cancer Screening Increase Your Efficiency and Value Antibodies, antigens,etc.for your research and discovery info@creative-biolabs.com www.antibody-creativebiolabs.com

  2. Tumor Markers in Cancer Screening It is known that tumors are caused by a combination of genetic and environmental factors. Their cells are characterized by unlimited proliferation. Usually, most tumors are asymptomatic in the early and middle stages. When patients with clinical symptoms come to the clinic, the tumor is too large to be removed, or it has entered the advanced stage, losing the best treatment opportunity. Therefore, early detection, diagnosis, and treatment of tumors are the key links in clinical cancer prevention and treatment. For early detection and diagnosis of tumors, a series of more valuable tumor markers have been used in clinical practice. Catalogue What are tumor markers? 2 ◆ How are tumor markers used in cancer care? 2 ◆ Do different cancer types need to be detected by different tumor markers? 3 ◆ 8 Does the rise in tumor markers mean the presence of cancer? ◆ Can tumor markers be used in cancer screening? 9 ◆ Is it necessary to detect tumor markers? 9 ◆ How to choose tumor markers？ 10 ◆ www.antibody-creativebiolabs.com 01 info@creative-biolabs.com

  3. Tumor Markers in Cancer Screening ◆ What aretumor markers? Tumor markers (TMs) refer to a class of substances that are directly produced by tumor cells or other cells of the body in response to tumors during its development and proliferation stages. Tumor markers essentially are proteins, hormones, enzymes (isozymes), polyamines, and oncogene products, which presents in the blood, body fluids, cells or tissues of patients. They can quantitatively and qualitatively reveal the presence of tumors, which provides strong experimental basis to estimate what the type of tumor is, what stage of the tumor has been developed to, the therapeutic effect and prognosis. ◆ How are tumor markers used in cancer care? 1. Auxiliary diagnosis and identification of tumors; 2. Screening high-risk populations of tumors; 3. Monitoring tumor recurrence and metastasis; 4. Observing tumor treatment and efficacy. www.antibody-creativebiolabs.com 02 info@creative-biolabs.com

  4. Tumor Markers in Cancer Screening ◆ Do different cancer types need to be detected by different tumor markers? Many tumor-related markers have been found, and nearly 100 kinds of them are of clinical value. Based on the chemical characteristics, they can be divided into the following seven categories: Embryonic antigen tumor markers Glycogen tumor markers Genomics tumor markers Hormone tumor markers Receptor tumor markers Enzyme tumor markers Protein tumor markers www.antibody-creativebiolabs.com 03 info@creative-biolabs.com

  5. Tumor Markers in Cancer Screening Embryonic Antigen Tumor Markers • Many proteins are secreted only during the embryonic stage, which stop producing after delivery. When a tumor occurs, these proteins will re-synthesize and be secreted, thereby being called embryonic antigen-like tumor marker. Alpha-fetoprotein (AFP)—liver cancer, spermatogonia. Embryonic antigen (CEA)—colorectal cancer, pancreatic cancer, lung cancer, breast cancer. Glycogen Tumor Markers • When normal cells are transformed into malignant cells, the glycoproteins on the cell surface will mutate to a specific antigen, which can be detected by monoclonal techniques. These antigenic substances presenting on the surface of tumor cells are called carbohydrate antigens (CA). CA125—ovarian cancer. CA15-3—breast cancer, ovarian cancer. CA19-9—pancreatic cancer, liver cancer, and gastrointestinal cancer. CA72-4—gastrointestinal cancer, pancreatic cancer, ovarian cancer. www.antibody-creativebiolabs.com 04 info@creative-biolabs.com

  6. Tumor Markers in Cancer Screening Hormone Tumor Markers • When a cell with a secretory hormone function is cancerous, it will secrete abnormal amount of hormones. Cells that do not produce hormones begin to produce hormones after canceration. Calcitonin (CT)—thyroid tumor. Human Chorionic Gonadotropin (hCG)—embryonal carcinoma, choriocarcinoma, non-spermatocytic carcinoma. Receptor Tumor Markers • Receptors are components existing on the cell membrane or in the cells, which are responsible for recognizing and binding to a biologically active molecule. It can correctly amplify and transmit the recognized and received signals to the interior of the cell, thereby causing biological effects. Estrogen Receptor (ER) and Progesterone Receptor (PR)—breast cancer. Epidermal Growth Factor (EGFR)—colorectal cancer, non-small cell lung cancer, head and neck cancer, breast cancer. www.antibody-creativebiolabs.com 05 info@creative-biolabs.com

  7. Tumor Markers in Cancer Screening Protein Tumor Markers • 2-2-microglobulin (β2-MG)—multiple myeloma, lymphoma, leukemia. Ferritin (SF)—liver cancer, lung cancer, leukemia, breast cancer. Thyroglobulin-thyroid cancer. Cytokeratin 19 fragment (Cyfra 21-1)—lung cancer, bladder cancer, prostate cancer, ovarian cancer, colorectal cancer, pancreatic cancer. Tissue polypeptide antigen (TPA)—bladder cancer, breast cancer, ovarian cancer, digestive tract tumors. Squamous cell carcinoma antigen (SCCA)—cervical cancer, lung cancer, head and neck cancer, nasopharyngeal cancer. Enzyme Tumor Markers • They are widely used for tumor treatment and prognosis monitoring because of their high sensitivity and low specificity. Alkaline phosphatase (ALP)—liver cancer, bone cancer, leukemia, sarcoma. Lactate dehydrogenase (LDH)—liver cancer, lymphoma, leukemia, ovarian cancer. Neuron-specific enolase (NSE)—small cell lung cancer, neuroblastoma, carcinoid, melanoma, pancreatic cancer. Prostate specific antigen (PSA)—prostate cancer. α-L-fucosidase(AFU)—primary liver cancer. www.antibody-creativebiolabs.com 06 info@creative-biolabs.com

  8. Tumor Markers in Cancer Screening Genomics tumor markers • Ras oncogene—pancreatic cancer, lung cancer, colon cancer, ovarian cancer, thyroid cancer, liver cancer, spermatogonia, kidney cancer. Her-2/neu (erbB2) oncogene—breast cancer, stomach cancer, ovarian cancer. Rb tumor suppressor gene—familial retinoblastoma, osteosarcoma, bladder cancer, breast cancer, lung cancer. P53 tumor suppressor gene—familial Li-Fraumen I syndrome, colon cancer, bladder cancer, stomach cancer, breast cancer, lung cancer, etc. www.antibody-creativebiolabs.com 07 info@creative-biolabs.com

  9. Tumor Markers in Cancer Screening ◆ Does the rise in tumor markers mean the presence of cancer? First of all, we must perform comprehensive detections before confirming a diagnostic cancer, through the methods of X-ray detection, CT detection, B-ultrasound detection, and pathological diagnosis. Since most tumor markers are not absolute specific products of malignant tumors, it is possible that false positives are in the detection of tumor markers. Elevated tumor markers are not the same as detecting cancer cells. Instead of indicating the presence of cancer, their presence may be caused by certain benign diseases or drugs. Many factors might be the reasons for the rise of tumor markers. For example, some benign inflammatory diseases will increase the amount of tumor markers. CA125 may also be elevated in benign, borderline tumors and endometriosis of the ovary. www.antibody-creativebiolabs.com 08 info@creative-biolabs.com

  10. Tumor Markers in Cancer Screening ◆ Can tumor markers be used in cancer screening? As some tumors do not secrete related proteins, and some tumor tissues have poor blood circulation, the tumor markers produced by them cannot be secreted into peripheral blood, which may lead to "false negatives" in tumor marker detection. If the tumor marker is normal, the probability of suffering from a related malignancy is relatively low. However, it needs to be reviewed regularly and diagnosed with other tests if the people have related family history, precancerous lesions or symptoms. In short, reasonable application and timely monitoring are the correct ways to clinically apply tumor markers. ◆ Is it necessary to detect tumor markers? Although tumor markers are not accurate enough, they can help doctors with the diagnosis, classification, prognosis, and treatment of tumors. It is not recommended to do tumor marker testing screening for asymptomatic populations, but high-risk groups should do screening once a year. Such as: 1. 45 years of age or older. 2. People with a genetic history of the tumor family, such as parents or grandparents in a family who have had cancer. 3. People with long-term inflammatory diseases. 4. People engaged in certain special occupations, such as frequent exposure to radioactive materials, toxic substances, or serious pollution in the working environment. 5. People with long-term bad habits, such as smoking, drinking, long-term staying up late or stressful. www.antibody-creativebiolabs.com 09 info@creative-biolabs.com

  11. Tumor Markers in Cancer Screening ◆ How to choose tumor markers? Most of single tumor markers cannot meet the clinical needs because of low sensitivity or specificity. In order to improve the value of auxiliary diagnosis and therapeutic monitoring of tumor markers, it is possible to select 2 or 3 complementary TMs for joint detection after scientific analysis and strict screening. Combined detection of tumor markers Cancer Preferred indicators Auxiliary indicators Colorectal cancer CEA, CA24-2 CA19-9 Pancreatic cancer CA19-9 CEA, CA24-2 Gastric cancer TCA72-4 CEA, CA19-9 Esophageal cancer CEA CA19-9, SCC Liver cancer AFP AFU, CEA, CA19-9,HCG Bile duct / gallbladder carcinoma CA19-9 CEA, CA24-2 Breast cancer HER2,CA15-3 CEA, CA125 Cervical cancer SCC CEA, CA125 Small Cell Lung Cancer NSE, ProGRP Prostate cancer PSA Bladder Cancer TPA, CEA, CA19-9 CYFRA21-1 Thyroid cancer Tg CEA Malignant melanoma S100 www.antibody-creativebiolabs.com 10 info@creative-biolabs.com

  12. Tumor Markers in Cancer Screening Featured antibodies for tumor markers Targets Clone Applications Species Reactivity Cat. CEA 161 ELISA, IP, WB Human CBMAB-XB0225-YC CA19-9 SPM588 FC, IHC-P, IF Human CBMAB-C1123-CQ CA19-9 CA19.9/1390R FC, IF, IHC-P Human CBMAB-C0512-CQ CA19-9 CBXC-2378 FC, IF, IHC-P Human CBMAB-C0012-CQ KLK3 IHC654 IHC-P, ELISA, IHC Human CBMAB-MA133-YC KLK3 D2A8 WB, IP, IF (ICC) Human CBMAB-CP2096-LY AFP IHC510 IHC Human CBMAB-MA007-YC AFP 4G2D2 ELISA, IHC Human CBMAB-R4290-CN AFP CBYC-A407 ELISA, WB, IHC-P Human CBMAB-A1569-YC S100 IHC100 IHC-P, ELISA, IHC Human CBMAB-MA214-YC CYFRA21-1 CBCNC-543 ELISA, WB Human CBMAB-C3276-CN CYFRA21-1 KS19.1 ELISA, WB Human CBMAB-C3275-CN hCG IHC593 IHC Human CBMAB-MA113-YC CGB NYRhCG ELISA Human CBMAB-C10939-LY CGA HCG 205 ICC, IHC Human CBMAB-C3841-CQ ERBB2 44E6 WB Human, Mouse, Rat CBMAB-CP0937-LY ERBB2 D8F12 WB, IHC-P Human, Mouse, Rat CBMAB-CP0935-LY ERBB2 4C10 WB, ELISA Human CBMAB-A2684-LY MUC16 IHC125 IHC-P, ELISA, IHC Human CBMAB-MA173-YC MUC16 OV185-1 ICC, IF, IHC-P Human CBMAB-C12102-LY Human, Mouse, Rat, Monkey ENO2 D20H2 WB, IP CBMAB-CP0592-LY ENO2 1A3 WB, ELISA Human CBMAB-A2614-LY www.antibody-creativebiolabs.com 11 info@creative-biolabs.com

  13. Tumor Markers in Cancer Screening About us • Since 2004, Creative Biolabs has been working on the development of tumor markers and the production of antibodies against tumor markers. At Creative Biolabs, we utilize advanced antibody research tools, professional technical support, and rapid global delivery to ensure quality for scientific research workers and customers in industry. We believe that to build up a custom-service-centered business model is crucial for optimizing the drug development process, leveraging accessible resources, and gathering a team from various backgrounds to conduct drug discovery projects in the future. As a preferred supplier for global customers, we are confident to provide you with first-class services covering a full range of applications. If you have any need for antibodies, please contact us. www.antibody-creativebiolabs.com 12 info@creative-biolabs.com

  14. Contact Us Tel: 1-631-381-2994 Fax: 1-631-207-8356 Email: info@creative-biolabs.com www.antibody-creativebiolabs.com 45-1 Ramsey Road, Shirley, NY 11967, USA Our promise: Guaranteed product quality, expert customer support. 13

More Related