Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection)

1. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) © The Swiss Pharmacy

2. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) is FDA approved for the treatment of hypogonadotropic hypogonadism, prepubertal cryptorchidism, and ovulation induction. HCG is a hormone that is used to cause ovulation and to treat infertility in women. This medicine is not effective in women with primary ovarian failure. In female infertility it can be used to cause women to ovulate (Ovulation induction). Eutrig-HP is also used along with other fertility medicines, to help produce eggs in medically assisted reproduction programmes (IVF treatment). Human Chorionic Gonadotropin Injections (HCG) is used in men to treat hypogonadism, a condition in which the body doesn't produce enough testosterone. HCG is also used in young boys whose testicles have not descended (dropped) into the scrotum as normally expected during growth. HCG is usually given for this condition in boys who are 4 to 9 years old. © The Swiss Pharmacy

3. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) © The Swiss Pharmacy

4. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) are manufactured by Samarth Life Sciences Private Limited, India in the strength of 2000iu, 5000iu and 10000iu. © The Swiss Pharmacy

5. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Chemical Structure © The Swiss Pharmacy

6. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) The active pharmaceutical ingredient in Eutrig-HP injections is Human Chorionic Gonadotropin. Each vial of Eutrig-HP injection contains 2000iu, 5000iu or 10000iu of purified Human Chorionic Gonadotropin. © The Swiss Pharmacy

7. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Uses of Eutrig-HP 2000iu, 5000iu and 10000iu Injections: Human Chorionic Gonadotropin (HCG), the active ingredient found in Eutrig- HP Injection is a hormone that supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation. HCG (Eutrig-HP Injections) is used to cause ovulation and to treat infertility in women, and to increase sperm count in men. HCG is also used in young boys when their testicles have not dropped down into the scrotum normally. This can be caused by a pituitary gland disorder. Chorionic gonadotropin injection is a hormone used as a fertility medicine to develop eggs in women who have not been able to become pregnant because of problems in ovulation. It is also used to help men with low sperm counts produce more sperms and used when testicles have not dropped down in the scrotum which is caused by a pituitary gland problem. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

8. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Uses of Eutrig-HP 2000iu, 5000iu and 10000iu Injections: In females, Chorionic Gonadotropin (Eutrig-HP Injection) is used to help conception occur. It is usually given in combination with other drugs such as menotropins and urofollitropin. Many women being treated with these drugs usually have already tried clomiphene alone and have not been able to conceive yet. Chorionic gonadotropin is also used in in-vitro fertilization (IVF) programs. In males, LH and chorionic gonadotropin stimulate the testes to produce male hormones such as testosterone. Testosterone causes the enlargement of the penis and testes and the growth of pubic and underarm hair. It also increases the production of sperm. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

9. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Recommended Adult Dosage The recommended dosage of Eutrig-HP Injections Human Chorionic Gonadotrophin Injections) for various indications is given below: Usual Adult Dose for Ovulation Induction: Usual Adult Dose for Ovulation Induction: Ovulation Induction (if the cause of anovulation is secondary and not due to primary ovarian failure): Chorionic Gonadotropin: Chorionic Gonadotropin: 5000 to 10,000 units IM one day following last day of menotropins. Recombinant chorionic gonadotropin: Recombinant chorionic gonadotropin: 250 mcg subcutaneously one day following last dose of follicle-stimulating agent. Eutrig-HP Injections (Generic URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

10. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Recommended Adult Dosage The recommended dosage of Eutrig-HP Injections Human Chorionic Gonadotrophin Injections) for various indications is given below: Usual Adult Dose for Hypogonadism - Male: Hypogonadotropic hypogonadism (secondary to a pituitary deficiency): 500 to 1000 units IM three times a week for 3 weeks followed by the same dose twice a week for 3 weeks or, 4000 units IM three times a week for 6 to 9 months followed by 2000 units three times a week for an additional 3 months. Eutrig-HP Injections (Generic URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

11. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Contraindications ➔Eutrig-HP Injections are contraindicated in patients with a known hypersensitivity to human gonadotropins, including hCG, or any component of the injection. ➔High serum FSH, indicating primary gonadal failure in women. ➔Presence of uncontrolled non-gonadal endocrinopathies (e.g., thyroid, adrenal, or pituitary Disorders). ➔Tumors of the hypothalamus or pituitary gland and ovary, breast, or uterus in females and breast or prostate in males. ➔Malformations of the reproductive organs incompatible with pregnancy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

12. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Contraindications ➔Fibroid tumors of the uterus incompatible with pregnancy. ➔Abnormal vaginal bleeding of undetermined origin ➔Also contraindicated in cases of Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

13. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Storage Instructions Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

14. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Warnings Human Chorionic Gonadotropin (Eutrig-HP Injections) should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions, and adverse reactions described in the package insert for menotropins. Anaphylaxis has been reported with urinary-derived HCG products. The principal serious adverse reactions during this use are: (1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain, and/or pleural effusion, (2) Rupture of ovarian cysts with resultant hemoperitoneum, (3) Multiple births, and (4) Arterial thromboembolism. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

15. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Warnings Since infertile women undergoing assisted reproduction, and particularly IVF, often have tubal abnormalities the incidence of ectopic pregnancies might be increased. Early ultrasound confirmation that a pregnancy is intrauterine is therefore important. Prior to treating patients for inadequate endogenous stimulation of the gonads, an examination should be performed to exclude anatomical abnormalities of the genital organs or nongonadal endocrinopathies (e.g. thyroid or adrenal disorders, diabetes). Primary ovarian failure should be excluded by the determination of gonadotrophin levels. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

16. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Warnings Patients with latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions) should be kept under close medical supervision, since aggravation or recurrence may occasionally be induced as a result of increased androgen production. Human Chorionic Gonadotropin (Eutrig-HP Injections) should be used cautiously in prepubertal boys to avoid premature epiphyseal closure or precocious sexual development. Skeletal maturation should be monitored regularly. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

17. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Possible Side Effects Stop using Human Chorionic Gonadotropin (Eutrig-HP Injections) and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache. Common Side effects of Eutrig-HP Injections (Human Chorionic Gonadotropin Injection) are Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, pain at the site of injection. Hypersensitivity reactions, both localized and systemic in nature, have also been reported. In rare cases generalized rash or fever may occur. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

18. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Eutrig-HP Injections Overdosage Seek emergency medical attention if you think you have used too much of this medicine. An overdose of HCG is not expected to produce life-threatening symptoms. Call your doctor right away if you have any symptoms of OHSS: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting, and urinating less than normal. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

19. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Eutrig-HP Injections During Pregnancy Human Chorionic Gonadotropin (Eutrig-HP Injections) is classified by the US FDA as Pregnancy Category category X. This means that using the medication once you are pregnant can cause birth defects in the baby. Do not use this medication if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Defects of forelimbs and central nervous system and alterations in sex ratio have been reported in mice receiving combined Gonadotropin and Chorionic Gonadotropin therapy in dosages to induce superovulation. Multiple ovulations with resulting plural gestations (mostly twins) have been reported to occur in approximately 20% of pregnancies when conception has followed Chorionic Gonadotropin therapy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

20. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Eutrig-HP Injections During Nursing It is not known whether Chorionic Gonadotropin (Eutrig-HP) is excreted in human milk. Since many medicines are excreted in human milk, caution should be exercised when Chorionic Gonadotropin is administered to a nursing woman. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy

21. Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) Eutrig-HP Injections Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) are manufactured by Samarth Life Sciences Private Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html https://www.theswisspharmacy.com/product_info.php?info=p9973_Generic-Human-Chorionic-Gonadotrophin-Injection.html © The Swiss Pharmacy