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Nikken Ciaga V Highest Antioxidant Superfruits

Ciaga V is a potent blend of Maqui Berry and Bergisterol superfruits rich in antioxidants, supporting cardiovascular, immune, gastrointestinal health, and anti-aging benefits. Learn about the origins, benefits, and traditional uses of Maqui Berry and Bergisterol for overall well-being.

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Nikken Ciaga V Highest Antioxidant Superfruits

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  1. Nikken Ciaga V Highest Antioxidant Superfruits Cardiovascular, Immune, Antioxidant, Gastrointestinal, and Anti-aging

  2. What’s in Ciaga V? • 5 Highest Antioxidant Superfruits: Maqui Berry, Elderberry, Acai Berry, Blackberry, Raspberry • Certified Organic US NOP and EU • 100% from pollution free native forest (Far from industrial, main roads, polluted water & air source) • 100% pesticides and herbicides free • Maqui Berry is wild harvested by the Mapuche Indians, utilizing sustainable harvesting practices

  3. What’s Maqui Berry? • Deeply purpled berry from Patagonia region • Harsh climate, sun irradiation, environment and biological enemies • Highest Antioxidant value as measured by ORAC • Broadest Antioxidant protection as measured by Total ORAC • High concentration of anthocyanins (especially the delpinidin) and polyphenols

  4. Traditional Use A sacred plant used in many ceremonial practices such as harvest, birth, marriage, death, and war. Traditionally used by the Mapuche Indians for: • increasing strength and stamina, • Creating body warmth during Winter • Boost Immune Health • Treat diabetes, cancer, fever, ulcer, child delivery

  5. Benefits of Maqui Berry • Very High level of Polyphenols • Highest Anthocyanins, especially delphinidin • Supports Healthy Aging • Protects Cells from Oxidative Stress • Neutralizes Free Radicals • Supports Healthy Immune & Inflammatory Function • Natural COX-2 Inhibitor • Supports Cardiovascular Health • Inhibits LDL Oxidation • Reduction of Insulin resistance • Possible weight loss benefits: Thermogenic

  6. Highest ORAC Compared to Any Fruit on the Planet * Data obtained from USDA ORAC report Nov 2007† Data value obtained from Independent Lab report from Brunswick Laboratories, MA

  7. ORAC hydro Comparison of Juices * Data value obtained from Independent Lab report from Brunswick Laboratories, MA †Data obtained from J Agric. Food Chem.,Vol 56, No 4, 2008

  8. Anthocyanins & Total Phenols (Fruits)

  9. Total Phenols in Juice • Provide plants with color • 4,000 known polyphenols

  10. Total ORAC Test • Original ORAC method only test against 1 free radicals---peroxyl.  • "Total ORAC test" measure 5 different radicals that are commonly found in human. - Hydroxyl - Peroxyl - Peroxynitrite - Singlet oxygen - Superoxide anion

  11. Total ORAC per oz

  12. Maqui Berry Inhibit LDL Oxidation and Protect Cells against Oxidative Stress • Oxidized LDL cause atherosclerosis - induces oxidative stress - develop fatty streak lesion in arterial wall • Fruit phenols protect cells from oxidative stress induced by different stressors • Maqui Berry: very high in phenols & antioxidant - Protects LDL from oxidation - Protects cells from oxidative stress

  13. TRAP & TAR TRAP: measure amount of free radicals that can be trapped TAR: capacity to decrease the steady-state free radical concentration Higher Phenols = higher TRAP & TAR (result based on single strength fruit brix)

  14. Anti-inflammatory Action NFkB • Key regulator of our immune and inflammatory response system • Controls pro-inflammatory cytokines that causes inflammation & pain Maqui berry inhibits NFkB --- turns off switch to inflammation --- reduce cytokines and enzymes that causes inflammation Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008

  15. Maqui Berry Activates PPAR gamma PPAR gamma Activation of PPAR gamma inhibition of NFkappaB reduction of COX-2 enzyme & prostaglandin level reduction in inflammation & pain Maqui berry activates PPAR gamma ---inhibits NF kappa B --- reduce COX-2 ---anti-inflammatory Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008

  16. Natural COX-2 Inhibitor • COX-2: responsible for inflammation and pain • Triggered by inflammatory cytokines and NFkappaB. • Cancer, Arthritis • 100mg/kg of Maqui significantly reduced COX-2 between 0 to 6 hours, effect similar to 2mg/kg of diclofenac (COX-2 inhibior drug) • Maqui berry inhibit NFkappaB --- Reduce COX-2 --- Natural COX-2 Inhibitor Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008 Completely erase COX-2 at 24 hours

  17. Effects of Maqui on Caco-2 Cancer Cell Completely eliminate Caco-2 cell at 4 hours, 8 hours, and 16 hours Evaluation and development of botanical drugs from Aristotelia Chilensis, 2008

  18. BergisterolsCholesterol, Blood Glucose, Weight Loss

  19. Citrus BergamiaRisso • Origin: Calabria, Italy • 95% worldwide production

  20. Health Benefits of Bergisterol • Cardiovascular Health • Reduce Total Cholesterol • Reduce LDL, inhibit LDL oxidation • Reduce Triglycerides • Increase HDL : inhibits plague formation • Reduce Blood Sugar Level (diabetic) • Improve Vasodilatation • Maintain Blood Pressure • Significant Reduction of Coronary Artery Disease risk • Weight Loss

  21. Statin Like Compounds in BergamonteJ Nat Prod. 2009 Jul;72(7):1352-4 • 3-hydroxy-3-methylglutaric acid (HMG) bound to neohesperidin (Brutieridin) and naringin (Melitidin) • Inhibits HMG reductase: key intermediate in cholesterol metabolism Brutelidin Melitidin

  22. Bergamonte Reduces Total Cholesterol, LDL, Triglycerides, and Blood Glucose in Wistar Rats Bergamonte Reduces Total Cholesterol, LDL, Triglycerides, and Blood Glucose in Zuker Rats

  23. Citrus Bergamia Protects Arteries from Injury 3 days after balloon injury +Bergamot 3 days after balloon injury 3 days control Balloon injury --- scar tissue formation, increased LOX-1, increase free radical Bergamot restores the antioxidant status ---- reduces free radical formation ---- reduces LOX-1 --- reduces injury arterial vessels

  24. Optimal Cholesterol Level

  25. Bergamot Juice Reduces Blood Levels of Triglycerides, Cholesterol and Blucose in 192 Metabolic Syndrome Patients after 30 days - High Risk Total Cholesterol (>240) • Low HDL-C (<40) • LDL-C: Borderline (130-159), High Risk (160-189), to Very High Risk (>190) • - High Risk Triglycerides (>200)

  26. Hypolipemic and Hypoglycemic Activity of Bergamot PolyphenolsFitoterapia 82 (Nov 2011) 309–316 Data is polled from 238 patients: (1) 82 patients with isolated hypercholesterolemia (LDL>130) (2) 76 patients with mixed dyslipedemia (hypercholesterolemia and hypertryglyceridemia) (3) 48 patients with mixed hyperlipemia and glycemia) (4) 32 patients previously on statin, 60 days wash out period

  27. Bergamonte vs Statins • Study design • Patients : 77 (38 male 39 womans) • Age: 61 + 6 • Inclusion criteria: LDLChol > 160 mg/dl + Triglycerides > 225 mg/dl • Prospective, open-label, parallel group, controlled study • Group 1 CTRL • Group 2 rosuvastatin 10 mg/day • Group 3 rosuvastatin 20 mg /day • Group 4 Bergamonte 1000 mg/day • Group 5 rosuvastatin 10 mg/day + Bergamonte 1000 mg/day

  28. Bergamonte vs Statins

  29. Common Side Effects of Statins • Muscle Pain and Damage • Liver Damage • Digestive Problems • Rash or Flushing • Neurological Side Effects • None with Bergamot

  30. Product Comparison

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