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Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation. Osteoscoop - Issue N°267 – December 2012. Cldn-18 -/-. Normal bone mass. Increase bone resorption. Low bone mass. Cldn-18 -/-. Normal bone mass. Increase bone resorption. Low bone mass.

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Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation

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  1. Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation Osteoscoop - Issue N°267 – December 2012

  2. Cldn-18-/- Normal bone mass Increase bone resorption Low bone mass

  3. Cldn-18-/- Normal bone mass Increase bone resorption Low bone mass Osteoclast progenitor ZO-2 RANKL RANK Osteoclast differentiation Bone resorption

  4. Cldn-18-/- Normal bone mass Increase bone resorption Cldn-18 Low bone mass PDZ domain - Osteoclast progenitor ZO-2 RANKL RANK Osteoclast differentiation Bone resorption

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