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Inpp4b as a regulator of bone mass

Inpp4b as a regulator of bone mass. Osteoscoop - Issue N°219 – January 2012. Preosteoclast. In vitro : Preosteoclast cellular expression Inpp4b a Inpp4b a mutant. -. Osteoclast differentiation Maturation. +. Osteoclasts. Preosteoclast. In vitro : cellular expression Inpp4b a

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Inpp4b as a regulator of bone mass

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  1. Inpp4b as a regulator of bone mass Osteoscoop - Issue N°219 – January 2012

  2. Preosteoclast In vitro: Preosteoclast cellular expression Inpp4ba Inpp4ba mutant - Osteoclast differentiation Maturation + Osteoclasts

  3. Preosteoclast In vitro: cellular expression Inpp4ba Inpp4ba mutant In vivo: KO Inpp4b-/- - Osteoclast differentiation Maturation + + Osteoclasts Reduce bone mass

  4. Preosteoclast In vitro: cellular expression Inpp4ba Inpp4ba mutant In vivo: KO Inpp4b-/- - Osteoclast differentiation Maturation + + Osteoclasts Reduce bone mass Preosteoclast P NFATc1-P NFATc1 Osteoclast specific genes NFATc1 Intracellular [Ca2+] RANK Inpp4ba - RANKL Endoplasmic reticulum

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