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Zero-Order Controlled Release Kinetics

Zero-Order Controlled Release Kinetics. Through Polymer Matrices. Kyle Douglas, James Farber, Steven Flynn, Janie Gu, Vivian Qin, Jenny Shih, Jake Silberg , Anita Wamakima. Dr. David Cincotta, Jeremy Tang. Controlled Release. Normally 1 st or 2 nd order 0 th order rare but essential

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Zero-Order Controlled Release Kinetics

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  1. Zero-Order Controlled Release Kinetics Through Polymer Matrices Kyle Douglas, James Farber, Steven Flynn, Janie Gu, Vivian Qin, Jenny Shih, Jake Silberg, Anita Wamakima Dr. David Cincotta, Jeremy Tang

  2. Controlled Release • Normally 1st or 2nd order • 0th order rare but essential • Goal: Use semipermeable membrane to keep rate of release constant

  3. Background • Began in late 1940’s & 1950’s • Applications: • Agriculture • Zoology • Cosmetics • Medicine • Environment

  4. Background

  5. Membrane: Polymers • Series of repeating monomers • Diverse properties: • Intermolecular forces • Molecular shape • Crystallinity • Use different properties to control release http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/polymers.htm

  6. Solubility Parameters • Predict solubility of different substances • Hansen solubility parameter • Equation:Ra2 = 4(δ D1 - δ D2) 2 + (δ P1 - δ P2) 2 + (δ H1 - δ H2) 2

  7. Hypothesis • Principle of “like likes like” • Closer solubility parameters  faster diffusion rate

  8. Polymers Tested • Polyethylene (C2H4) • Ethylene-Vinyl Acetate (EVA) Copolymer • Vinyl Acetate (CH3COOCH=CH2) • 10% • 12% • Rest is ethylene (C2H4)

  9. Substances Released

  10. Apparatus

  11. Schematic of the Apparatus

  12. Data

  13. Rates of Evaporation

  14. Conclusion • Zero-order release was achieved using the mechanism • Solubility parameters did not account for numerous other factors

  15. Future Studies • Mixtures of molecules (i.e. perfume) • Other properties of polymers • Size • Explore solubility parameters in-depth • Non-volatile substances – different apparatus

  16. Acknowledgements • Dr. David Cincotta, mentor • Jeremy Tang, assistant • Sig Sigamani of Celanese Corporation and Stephen Takacs, providing polymers • Dr. David Miyamoto, director • NJGSS and sponsors, opportunity

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