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Research update 2014

Research update 2014. Shubhayan Sanatani, MD, FRCPC, CCDS, FHRS Vice-President, Research. Study proposals. Attempting to run all PACES studies through the PACES Research Committee (PRC) To ensure in alignment with PACES mission To ensure not multiple competing studies Advantages:

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Research update 2014

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  1. Research update 2014 Shubhayan Sanatani, MD, FRCPC, CCDS, FHRS Vice-President, Research

  2. Study proposals • Attempting to run all PACES studies through the PACES Research Committee (PRC) • To ensure in alignment with PACES mission • To ensure not multiple competing studies • Advantages: • Access broader group • “Second set of eyes” • Less likely to “get scooped”

  3. Process • Send protocol and data collection to VP Research • Can be at any stage • Pre-IRB approval • Early concepts • Post-IRB • Good idea to circulate to somebody first • 2 PRC members review

  4. Some highlights from 2013-14 • First PRC Newsletter! • Several PACES publications

  5. ISPRINT summary • 49 attendees • Saarel – ICD programming registry • Aziz – Dofetilide • Papagiannis – AVNRT in CHD • Escudero/Sanatani – neurodevelopment in SVT • Etheridge – WPW + Arrest/A fib • Seslar/Sanatani/Blaufox – Infant SVT Registry

  6. PRC meeting summary • Standing room only! • CRT registry - Silva • 3830 Lead - Moak • SUD in Duchenne – Kertesz • HCM Risk stratification - Balaji • Fetal LQTS - Cuneo • Gene discovery - Ackerman • Non-fluoro registry - Clark

  7. The Paul C. Gillette Pediatric and Congenital Electrophysiology Society Research Grant 2014 This award is sponsored by the family of Paul C. Gillette to support the spirit of discovery that he dedicated his career to.

  8. Inaugural PCG Winner Molecular Basis of Circadian Variation in Arrhythmias in CPVT

  9. The SADS Foundation’s Courts K. Cleveland, Jr. Young Investigator Award For excellence in the field of Cardiac Channelopathy Research

  10. SADS YIA 2014: Basic • Nicole Boczek • Supervisor: Mike Ackerman • Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring Kv4.3 Protein Inhibitor and its contribution to Brugada Syndrome

  11. SADS YIA 2014: Clinical • Jamie Kapplinger • Supervisor: Mike Ackerman • Enhanced Classification of Brugada Syndrome- and Long-QT syndrome-Associated Genetic Variants in the SCN5A-Encoded Nav1.5 Cardiac Sodium Channel

  12. Farewell and thanks to…

  13. Strategic planning highlights • “it was not as bad as I thought it would be” • Everyone • “Shu, you have been talking all day…I am sick of listening to you…” • Maully Shah

  14. Goals for 2014-15 • Show me the money! • And the focus… • Activate website • Research projects • With links to protocols! • Catalogue past successes on website – Webster • Awards, publications

  15. May 13-16, 2015 Boston PACES RESEARCH MEETING May 12, 2015 8am…

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