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Research Update

Research Update. Sukhi Basati PhD Candidate Laboratory for Product and Process Design Director: Prof. Andreas Linninger 2/3/2011. Microcontroller Unit. Shunt. Subcutaneous. 3.4 mm. 350 µm. Thesis aims. An implantable system for intracranial volume measurements in hydrocephalus.

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Research Update

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  1. Research Update Sukhi Basati PhD Candidate Laboratory for Product and Process Design Director: Prof. Andreas Linninger 2/3/2011

  2. Microcontroller Unit Shunt Subcutaneous 3.4 mm 350 µm Thesis aims An implantable system for intracranial volume measurements in hydrocephalus • Develop sensor based on an impedance technique to measure volume • Computer aided design • Microfabricate sensor with biocompatible materials • Electronics design and fabrication • Bench-top analysis to optimize parameters • Validate measurements in an acute hydrocephalic animal model • Animal protocol to induce HC and implant sensor into hydrocephalic rat • Develop chronic, implantable measurement device • Wireless data communication and microcontroller implementation

  3. Spring 2011 research aims • Initiate HC experiments on west campus • Priority: High • Induce HC in weanling rats (only need n=10) (experiments should not last longer than end of February) • 2nd surgery involves implanting sensor into hydrocephalic ventricles and CSF removal • Submit acute volume measurement paper • Priority: High • JNS - pediatrics • Design and fabricate long term electronics consisting of surface mount components (microcontroller + wireless transmitter) • Priority: Medium • Write draft of HC simulation in weanling rats • Priority: Medium

  4. Paper Review Age-dependence of intracranial viscoelastic properties in living rats Alexander V. Shulyakov, Stefan S. Cenkowski, Richard J. Buist, Marc R. Del Bigio

  5. Ideally: Perhaps: Or: Instrumentation Pump CSF 4.8 mm 500 µm Acute HC Measurements • Some problems… • Still cannot remove CSF. • We observe CSF leakage. • Is it possible that ventricle collapses, and we are trying to remove fluid from ECS?

  6. Rat CSF Simulations Hypothesis: CSF flows can be predicted in different stages of hydrocephalus and the expansion of the ventricles results in tissue strain in localized regions. • Model Geometry: • Ventricles • SAS • Brain Parenchyma • Next steps: • Work with Forrest on 2d model Simple geometry 21d HC geometry

  7. Power Control Circuit Power Control Circuit ? • Requirements: • Power switch controlled by microcontroller • Supply positive and negative voltages to all integrated circuits • Options: • Transistor as switch with a single or dual power supply. (Single battery can supply positive and negative voltages? – It depends) • Use relay (draws too much current)

  8. Future Work • Purchase pressure transducer • Simulate Rat CSF dynamics and ventricular expansion • Develop power control circuit • Prepare DMD talk • Work with undergraduates

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