Risk factors of Rheumatoid Arthritis

2. Understanding Rheumatoid Arthritis Rheumatoid arthritis (RA) is an autoimmune disease causing the immune system to mistakenly attack its tissues. It primarily affects the synovium, the lining of the membranes surrounding the joints. Symptoms include joint pain, swelling, stiffness, and eventual joint damage. At India’s top regenerative rehabilitation centre, we offer customized and holistic rehabilitation programs to manage RA effectively.

3. Risk Factors of Rheumatoid Arthritis Genetic Risk Factors • Genetic Predisposition: Significant role in the development of RA. Certain genetic markers, like the HLA-DRB1 gene, are strongly associated with increased susceptibility. Family history of RA increases the likelihood of developing the condition. Gender and Age Risk Factors • Gender: RA is more prevalent in women than men. Hormonal differences contribute to this disparity. Women are two to three times more likely to develop RA. • Age: Onset is most common between ages 40 and 60. Juvenile rheumatoid arthritis (JRA) affects children, indicating RA is not confined to older adults. Risk factors for JRA are similar to late-onset RA, with family history playing a key role.

4. Risk Factors of Rheumatoid Arthritis Lifestyle Risk Factors • Smoking: Increases likelihood of developing RA and exacerbates its severity. Smokers with RA experience more severe symptoms and faster disease progression. • Obesity: Excess weight stresses joints and produces pro-inflammatory cytokines. • Gum Disease: Significant factor in RA, lung disease, heart disease, and Alzheimer’s. Harmful bacteria can lead to severe inflammation in the lungs and joints. • Diet: Avoiding red meat, dairy, sugar, and high-fructose syrup while emphasizing fish, vegetables, and olive oil can help prevent arthritis. • Changes in the Microbiome: Imbalances in gut and oral microbiomes can lead to inflammation and RA. Factors like diet, antibiotics, and lifestyle can disrupt this balance.

5. Environmental Risk Factors • Exposure to Toxins: Asbestos, silica, and pesticides linked to increased RA risk. These toxins trigger chronic inflammation and autoimmune responses. • Infections: Epstein-Barr virus and hepatitis C are associated with higher RA risk. Infections alter immune function and trigger autoimmune responses. • Air Pollution: Chronic exposure to fine particulate matter causes systemic inflammation, contributing to RA development.

6. Rheumatoid Arthritis Precautions • Healthy Diet: Anti-inflammatory foods like omega-3 fatty acids (fish, flaxseeds, walnuts) reduce inflammation. Antioxidant-rich fruits and vegetables support overall health. • Regular Exercise: Low-impact exercises (swimming, walking, yoga) maintain joint flexibility and reduce inflammation. Strength training supports joint health by strengthening surrounding muscles. • Quitting smoking: Quitting smoking is crucial as it worsens RA progression and reduces treatment effectiveness. Avoiding smoking improves health outcomes for RA patients. • Weight Management: Maintaining a healthy weight reduces joint stress, inflammation, and pain. • Diet and exercise alleviate symptoms and improve quality of life.

7. Stem Cell Therapy at Plexus At Plexus, we use mesenchymal stem cells (MSCs) to suppress inflammation and mediate immunomodulation. MSCs are sourced either from donors or from the patient’s own body. They are typically isolated from adipose tissue, bone marrow, and umbilical cord tissue. Key Properties of MSCs • Anti-Inflammatory Effects: Reduce localized inflammation in the joints • Immunomodulation: Regulate the immune system by suppressing inflammatory responses • Tissue Regeneration: Differentiate into bone and cartilage cells to repair damaged tissues • Low Risk of Immune Rejection: Generally well-tolerated by the immune system

8. Comprehensive Care at Plexus In addition to stem cell therapy, our customized rehabilitation for RA also features the following: • Physical therapy, occupational therapy, nutritive therapies, pain management • Fall prevention training, emotional counseling, caregiver support • Other therapeutic interventions to help patients live a full and pain-free life

9. Understanding and addressing RA risk factors aids in early detection and better management. Lifestyle modifications like quitting smoking, maintaining a healthy weight, and following a balanced diet reduce RA risk and impact. Contact Plexus for more information on our rehabilitation program for rheumatoid arthritis. WhatsApp: +91 89048 42087 Call: +91 78159 64668 (Hyderabad) | +91 82299 99888 (Bangalore)