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1. Megaloblastic Anemias

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1. Megaloblastic Anemias

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    2. 1. Megaloblastic Anemias Two principal types pernicious anemia (B12) folate deficiency Common characteristics B12 and folic acid - Coenzymes for synthesis of thymidine ?impaired DNA synthesis ?delay or block in cell division blood and bone marrow changes Morphology Peripheral blood pancytopenia RBC - ***Macrocytic and oval (macro- ovalocytes) but Normochromic, Anisocytosis WBC Neutrophils larger, hypersegmented Marrow Hyperplastic All myeloid lineages are affected (giant metamyelocytes) Megakaryocytes -bizarre, multilobate nuclei , large

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