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CELL -CELL INTERACTIONS CH 11

CELL -CELL INTERACTIONS CH 11. Explain why this is the result of cell to cell communication. What characteristics are noted about cell communication here ?. I. Evolution of Cell Communication. Bacteria communicate with each other in order to respond to environmental changes

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CELL -CELL INTERACTIONS CH 11

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  1. CELL -CELL INTERACTIONSCH 11 Explain why this is the result of cell to cell communication

  2. What characteristics are noted about cell communication here ?

  3. I. Evolution of Cell Communication • Bacteria communicate with each other in order to respond to environmental changes • The mechanism of cell communication is similar in both prokaryotes and eukaryotes: • o Signal molecule secreted by one cell binds to receptor on target cell • o Target cell responds • what does this tell us about the evolution of cell communication?

  4. . II. How cells communicate with each other A. Local signaling: Direct contact and cell-cell recognition

  5. B. Local signaling using local regulators: paracrine and synaptic signaling • Signal molecules only travel short distances

  6. C. Long distance signaling: endocrine signaling • Involves hormones

  7. What characteristics are fundamentally the same in cell communication across the domains? • What allows a cell to respond to a signal?

  8. III. The transmission of a signal from one cell to another: A. The 3 stages of cell signaling: • Reception: • Transduction: • Response:

  9. Identify similarities and differences in these 2 modes of cell communication

  10. B. Reception • signal molecule binds to receptor causing it to change shape and become activated • this binding is specific 1. cell surface receptors: • hydrophilic signal molecules bind to receptors that span the cell membrane

  11. 2. If it a steroid hormone (lipid soluble): • Steroid diffuses across phospholipid bilayer, binds to its receptor in the cytoplasm, and travels to nucleus and either increases or decreases expression of certain genes

  12. http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter18/animation__mechanism_of_steroid_hormone_action__quiz_1_.htmlhttp://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter18/animation__mechanism_of_steroid_hormone_action__quiz_1_.html

  13. C. Signal Transduction :usually involves multiple steps

  14. Identify the 3 stages of cell signaling in this diagram • What is happening during transduction?

  15. Binding of signal activates receptor • the receptor activates another protein, which activates another, and so on, until the protein producing the response is activated

  16. Multistep pathways can amplify a signal: A few molecules can produce a large cellular response http://highered.mcgraw-hill.com/sites/0072437316/student_view0/chapter7/animations.html

  17. D. Response: • Ultimately, a signal transduction pathway leads to regulation of one or more cellular activities • The response may activate transcription

  18. The response may occur in cytoplasm

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