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Medical mycoses

Medical mycoses. cutaneus subcutaneus systemic opportunistic. Intact skin and mucosal surfaces serve as barriers to infection by mycotic agents. Fatty acid,pH,epithelial turnover of the skin Transferrin  to restrict the growth of several fungi.

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Medical mycoses

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  1. Medical mycoses cutaneus subcutaneus systemic opportunistic

  2. Intact skin and mucosal surfaces serve as barriers to infection by mycotic agents. • Fatty acid,pH,epithelial turnover of the skin • Transferrin  to restrict the growth of several fungi. • Superficial fungi dont elicit a cellular response from the host

  3. Etiology • Mallassezia furfur • Pityriasis Versicolor • Lipophillic organism • Lesion: hypopigmented area contain budding yeast cells and hyphae • Asymptomatic • Diagnosis: KOH preparations(skin scrapping)

  4. Dermatophytes • Dermatophytoses(Tinea,ringworm) • Infect keratinized structures • Skin,hair and nail • Invasive properties • May evoke inflamatory reaction • Three genera: - Epidermophyton - Trichophyton - Microsporum

  5. Anthropophillic • Zoophillic • Geophillic Tinea  chronic infection (warm and humid areas of the body) Typical lesion : inflame circular border containing papules & vesicles surrounding a clear area.

  6. Broken hairs and thickened broken nails Trichophyton • tinea capitis in children • Endothrix infections • “favus” tinea capitis in which crusts on the scalp.

  7. Dermatophytid (“id”) reactions - vesicles on the fingers - response to circulating fungal antigens - the lesion do not contain hyphae • Skin test with fungal extracts,eg, trichophytin

  8. The normal skin is generally resistant to invasion by dermatophytes • In conditions of excessive moisture,can invade keratinized structures.

  9. Laboratory diagnosis • Microscopic  KOH preparation scrappings of skin or nail  show hyphae 2. Cultures on Sabouraud’s agar typical hyphae and conidia 3. DNA probes 4. Test for the presence of fungal antigens or antibodies to fungal antigens.

  10. Tinea • Tinea capitis • Tinea barbae • Tinea axillaris • Tinea corporis • Tinea cruris  jock itch • Tinea pedis  athlete’s foot

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