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Is HMB the key?

Is HMB the key?. H M B. Tony Chao. Background info. Beta- hydroxy -beta- methylbutyrate (HMB) Discovered by Dr. Steven L Nissen , dept of animal science, Iowa St Univ Produced from Leucine and a - ketoisocaproate (KIC) via KIC- dioxygenase Synthesized in the body

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Is HMB the key?

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  1. Is HMB the key? H M B Tony Chao

  2. Background info • Beta-hydroxy-beta-methylbutyrate (HMB) • Discovered by Dr. Steven L Nissen, dept of animal science, Iowa St Univ • Produced from Leucine and a-ketoisocaproate (KIC) via KIC-dioxygenase • Synthesized in the body • Food sources: alfalfa sprouts, grapefruit, catfish, asparagus, avocado • Sold as supplement to increase muscle gains and fat loss

  3. Rowlands & Thompson, 2009 What are the claims? • Act as anti-catabolic agent • Attenuate proteolysis via down regulation of proteolytic pathways • Mechanism unclear • Increase lean muscle mass  increase maximal strength • HMB  HMG-CoA, provide carbon source for cholesterol synthesis  muscle hypertrophy • Improve body composition • Increase fatty-acid oxidation • Mechanism unknown

  4. Rowlands & Thompson, 2009

  5. Rowlands & Thompson, 2009

  6. Rowlands & Thompson, 2009

  7. Rowlands & Thompson, 2009

  8. Gallagher et al., 2000 Training adaptation may attenuate exercise induced muscle damage (Rowlands & Thompson, 2009)

  9. Results • Increase strength • Trained – trivial • Untrained – small effect (lower body) • Increase muscle mass • Trivial • Increase fat loss • Trivial • Improved body composition • Trivial

  10. Conclusion • May initially be beneficial to untrained men starting a strength training program • May be of little worth to highly trained men • Up to ½ HMB excreted in urine (Nissen & Abumrad, 1997)

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