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ALSPAC Data Resource: Overview and Study Design

An overview of the Avon Longitudinal Study of Parents and Children (ALSPAC), a cohort study designed to examine the influence of genetics and environment on health and development. This resource provides information on data sources, study design, questionnaires, hands-on assessments, biological samples, and access to the datasets.

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ALSPAC Data Resource: Overview and Study Design

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  1. An Overview Of TheALSPAC Data ResourceRSS Avon Local Group Meeting26th May 2009 David Herrick david.herrick@bristol.ac.uk http://www.bristol.ac.uk/alspac/

  2. What is ALSPAC? • “Avon Longitudinal Study of Parents and Children” • Cohort study of children and their parents, based in the former county of Avon (excluding Bath) • Designed to determine ways in which the individual’s genotype combines with environmental pressures to influence health and development

  3. Study design • Eligibility criteria: Mothers had to be resident in the study area and have an expected date of delivery between 1st April 1991 and 31st December 1992 • Avon was broadly representative of the UK as a whole and has a relatively stable population • Core sample of 14,541 pregnancies resulting in 14,062 live born children

  4. Data Sources • Self Completion Questionnaires • Hands on Assessments • Biological Samples • DNA • Direct School Contact • Health Records • Linked Datasets • Sub Studies

  5. Self completion questionnaires (1) • Carer (17, 4 during pregnancy) • Mother’s health, home environment, income, education, employment etc. • Partner (15, 2 during pregnancy) • Child-based, completed by main carer (23) • Child’s health, development, behaviour, diet etc. • Child-completed (22) • Teeth, school, home, hobbies, substance use, mental health etc. • Annual puberty questionnaires (9) • Tanner staging, menarchy

  6. Self completion questionnaires (2) • Miscarriages • Adult Learning (Carer & Partner) • Single mail shot; follow up telephone interview • DCSF Year 11 (Carer & Child) • Education - attitudes & aspirations • Friendships (Child) • Single mail shot; aim to identify which other study children child is friends with

  7. Hands on assessments (1) • Children in Focus • 10% sample seen 10 times between 4 & 61 months • 1432 attended at least 1, 1000 at least 8, 539 all 10 • Physical measures: Anthropometry, blood pressure, lung function, skin, hair & eye observations, allergy testing, vision, hearing, dental • Cognitive measures: habituation, memory, speech • Environmental measures: diet, pollution, parenting, day care • Blood samples

  8. Hands on assessments (2) • Focus Sessions • Annual assessments, starting with Focus@7, to which the whole cohort is invited • Physical: Measures, bone density, fitness, vision, hearing, allergies, blood / saliva samples, vascular function, lung function, acne • Cognitive / behavioural: IQ, speech & language, bullying, antisocial activities, friends, substance use, romantic relations, psychosis, depression

  9. Biological samples • Maternal blood & urine • Paternal blood & saliva • Umbilical cord blood & slices • Placentas • Children’s teeth, hair and nail clippings • Children’s blood, saliva & urine

  10. DNA • DNA for: • ~10,000 children • ~10,000 mothers • ~1,000 partners • ~6700 mother/child pairs • ~700 trios • Blood for cell lines for: • ~7,000 children • ~5,700 mothers • ~1,400 fathers

  11. ALSPAC at School

  12. Direct School Contact (1) • Contact with ~350 primary schools in the four local LEAs: • Bristol • South Gloucestershire • North Somerset • Bath and North East Somerset • Private & special schools included • Parental contact for out of area cases

  13. Direct School Contact (2) • Questionnaires in Year 3 & Year 6: • School (Head teacher) • Class (Class teacher) • Child (Class teacher) • Maths test in Year 4 • Maths, Spelling & Science tests in Year 6 • Year 6 maths test repeated in Year 8

  14. Health Records • Delivery notes • Abstracted by midwives • ~ 8300 in full • ~ 2300 shortened version • ~ 2000 further planned • Convulsions (n  400) • Hospital admissions • Selected from questionnaire responses • Special Care Baby Unit (n  1000)

  15. Linked Datasets • ONS Tracing • Electronic antenatal & birth records • National Pupil Database • Address based • Currently investigating PCT data, HES, Home Office, DWP, HESA

  16. Sub Studies (1) • Avon Brothers and Sisters Study • Becoming a Teenager • Before Breakfast Study • Being 3 • British Gas Study • Bunk Bed Study • DATE (diet and physical activity study) • Deuterium • Family Study • Four Seasons (physical activity calibration study)

  17. Sub Studies (2) • Fractures • Identifying Developmental Impairments • K4 (physical activity calibration study) • Lightbox (as an alternative to anthropometery) • Noise Study • Peanut & Other Allergies • Scan and Swim • Teenager at Thirteen • Twins Secret Language

  18. Response Figures Jan 2002

  19. Data Access Model • Contact ALSPAC via email • Receive CD/Download guide to Data sets • Download Research Proposal Form • Incorporates Data Agreement Form • Submit proposal to ALSPAC Exec • Receive dataset limited to research question/s • Variables are identified by collaborator • Built by ALSPAC statisticians/data staff • Extensions require further submission

  20. Publications

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