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Renal Pathology, Case 1

Renal Pathology, Case 1. A 32-year-old woman presents to the emergency room with acute onset of fever, chills, and right flank pain. WBC. Describe the lesion. White Blood Cell Cast A microscopic analysis reveals a protein cast containing white blood cells.

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Renal Pathology, Case 1

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  1. Renal Pathology,Case 1 • A 32-year-old woman presents to the emergency room with acute onset of fever, chills, and right flank pain.

  2. WBC Describe the lesion White Blood Cell Cast A microscopic analysis reveals a protein cast containing white blood cells. Compared to RBC casts, the WBC's are larger, have nuclei, and contain cytoplasmic granules. The cast takes the shape of the renal tubule. What is the most probable disease associated with this urine finding? Acute pyelonephritis. WBC casts can also be seen with interstitial nephritis

  3. Compare WBC and RBC cast Red Blood cell White Blood Cell Cast Red Blood Cell Cast A microscopic urinalysis reveals a protein cast containing red blood cells. The RBC's are anucleate.

  4. Describe the histologic findings A – WBC Cast B – Neutrophil C - Neutrophil Acute Pyelonephritis The microscopic section of the kidney reveals a large white blood cell cast in a tubule. Neutrophils infiltrate the interstitium. Correlate the pathologic finding in this slide with the urine finding in the previous slide.

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