DNA Damage

1. Gene Function Role DNA Damage FANCG Double Strand Break Repair Homologous Recombination PMS1 MLH1 Binding Mismatch Repair Metabolism GAD1 Glutamic acid carboyxlase Glutamate Metabolism GBE1 Glycosidic Bond formation Glycogen synthesis ALDH6A1 Aldehyde Dehydrogenase Carbohydrate Metabolism AGPAT1 LPA acetyltrasferase Phosphatidic Acid Metabolism ALDH1A3 Aldehyde Dehydrogenase Carbohydrate Metabolism HEXA Hexoamidase Ganglioside Metabolism SOAT1 Acetyl Transferase Cholesterol Metabolism FMO4 TMA Oxidase Amino Acid Metabolism NDUFB5 Oxidoreductase Electron Transport NDUFB7 Oxidoreductase Electron Transport COX5A Cytochrome c oxidase Electron Transport SDHA Succinate dehydrogenase Electron Transport PKLR Pyruvate kinase Glycolysis Apoptosis CASP6 Caspase Pro-Apoptotic PEA15 DED Containing Apoptosis CASP3 Caspase Pro-Apoptotic DAP1 IFG Signalling Pro-apoptotic TRADD TNF Signalling Pro-Apoptotic TNFRSF10D TRAIL Decoy Receptor Anti-Apoptotic Cell Signalling EPHB1 Tyrosine Kinase Signalling ARHGAP1 Rho GAP Signalling MAPKAPK3 Mitogen Signalling MAPK Pathway FGR Tyrosine Kinase Cell Migration MAPK10 Mitogen Signalling MAPK Pathway RAF1 MAP3K MAPK Pathway FGF2 FGF signalling Signalling FGFR4 FGF Signalling Signalling IGF2 Mitogen Signalling Signalling PPARG Transcriptional Control Signalling RAC1 GTPase Ras Signalling Transport SLC2A5 Glucose/Fructose Transport Solute Carrier AP1G1 Clathrin Vesicles Ligand-Receptor Transport KCNMB1 Potasium Channel Ion Channel SLC16A2 Organic Solute Carrier Solute Carrier ATP5C1 Proton Channel ATP Synthesis SLC19A1 Folate Transport Solute Carrier SEC61B ER Channel Protein Translocation ABCG1 ABC transporter Cholesterol/phospholipid transport SLC22A1 Organic Cation Transport Solute Carrier SLC16A4 Monocarboxylic acid transport Solute Carrier ATP6V0B V-Type ATPase pH Regulation Table S2: mRNAs Down-regulated during TRAIL induced apoptosis