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Welcome. Learning objectives Develop basic understanding of nonlinear regression and non-linear mixed effects methods Build basic population pharmacokinetic models in NONMEM Create informative graphical analysis Conduct such or more complex analyses with minimal supervision
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Welcome • Learning objectives • Develop basic understanding of nonlinear regression and non-linear mixed effects methods • Build basic population pharmacokinetic models in NONMEM • Create informative graphical analysis • Conduct such or more complex analyses with minimal supervision • Understand the application of these methods to drug development and regulatory decisions • To make this course mutually useful • ASK QUESTIONS • AsK quEsTioNs • aSk QuesTIons Introduction
Course format • Session I • Introduction to population pharmacokinetics • Session II • Population pharmacokinetic model building • Session III • NONMEM estimation methods • Session IV • Journal club meeting Introduction
Today’s agenda • Introductions • Q & A on session 1 • Q & A on homework assignment 3 • Lecture 1 (Dr. Christoffer Tornoe) • 10:30 AM-11:30 AM (60 mins) • Break • Lecture 1 continued • 11:45 AM-1:00 PM (75 mins) • Lunch break • Lecture 2 (Dr. Pravin Jadhav) • 2:00 PM-3:00 PM (60 mins) • Break • Lecture 2 continued • 3:15 AM-4:30 PM (75 mins) Introduction