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Date ______. Chapter 7 - Membrane Structure & Function. Membrane structure, I. Selective permeability Amphipathic hydrophobic & hydrophilic regions Singer-Nicolson: fluid mosaic model. What structure looks familiar?. Membrane structure, II. Phospholipids membrane fluidity Cholesterol

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  1. Date ______ Chapter 7 - Membrane Structure & Function

  2. Membrane structure, I • Selective permeability • Amphipathic • hydrophobic & hydrophilic regions • Singer-Nicolson: • fluid mosaic model

  3. What structure looks familiar?

  4. Membrane structure, II • Phospholipids • membrane fluidity • Cholesterol • membrane stabilization • “Mosaic” Structure • Integral proteins • transmembrane proteins • Peripheral proteins • surface of membrane • Membrane carbohydrates • cell to cell recognition • oligosaccharides (cell markers) • glycolipids; glycoproteins

  5. What looks familiar?

  6. Membrane structure, III • Membrane protein function: • Transport • Enzymatic activity • Signal transduction • Intercellular joining • Cell-cell recognition • ECM attachment

  7. What looks familiar?

  8. Membrane traffic • Diffusion • tendency of any molecule to spread out into available space • Concentration gradient • Passive transport • diffusion of a substance across a biological membrane • Osmosis • the diffusion of water across a selectively permeable membrane

  9. Seen on “U-tube” Extremely important. Let’s model this.

  10. Water balance in cells • Osmoregulation • control of water balance • Hypertonic • higher concentration of solutes • Hypotonic • lower concentration of solutes • Isotonic • equal concentrations of solutes • Cells with Walls: • Turgid (very firm) • Flaccid (limp) • Plasmolysis~ plasma membrane pulls away from cell wall

  11. Hippo and the hyper person

  12. Specialized Transport • Transport proteins • Facilitated diffusion • passage of molecules and ions with transport proteins across a membrane down the concentration gradient • Active transport • movement of a substance against its concentration gradient with the help of cellular energy

  13. How to get into the club…

  14. Types of Active Transport • Sodium-potassium pump • Exocytosis • secretion of macromolecules by the fusion of vesicles with the plasma membrane • Endocytosis • import of macromolecules by forming new vesicles with the plasma membrane • phagocytosis • pinocytosis • receptor-mediated endocytosis (ligands)

  15. Wheel on the bus go…

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