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Inflammation and Course Themes

Inflammation and Course Themes. Nancy Long Sieber, Ph.D. Sept. 14, 2009. Challenges and Adaptation. http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gif. http://www.siumed.edu/~dking2/crr/images/CR007b.jpg. What is the significance of injury and toxicity?.

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Inflammation and Course Themes

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  1. Inflammation and Course Themes Nancy Long Sieber, Ph.D. Sept. 14, 2009

  2. Challenges and Adaptation http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gif

  3. http://www.siumed.edu/~dking2/crr/images/CR007b.jpg

  4. What is the significance of injury and toxicity? • Tissues differ in their capacity for repair • Epithelial cells are continuously replaced • Nerve cells, in general, do not divide • Organs also differ in their “safety factors” • All organs have some amount of excess capacity • With aging and injury, the excess capacity is lost, and this may lead to loss of function

  5. http://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpghttp://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpg

  6. Elevator cable for passenger elevators has a safety factor of about 11 http://www.gkivdo.com/gkii/wire_3.jpg

  7. Necrosis and Apoptosis http://pubs.niaaa.nih.gov/publications/arh25-3/image01.gif

  8. Developing human hand before web apoptosis http://www.i-am-pregnant.com/img/day48-hand.gif

  9. Developing hand after web apoptosis http://www.grg.org/breakingnews2001.htm

  10. Modified from: http://www.chrononhotonthologos.com/inactive/strokedr/hbothera.htm

  11. Inflammation http://www.uic.edu/classes/bios/bios100/lecturesf04am/inflammation01a.jpg

  12. Inflammation Pro-inflammatory cytokines IL-1 IL-6 TNF Positive acute phase reactants: LIVER Haptoglobin C3 Fibrinogen Serum amyloid A C-reactive Protein

  13. http://www.easterncarolinaent.com/Allergy-Triggers-copy.jpg Common Allergens

  14. http://www.euromeds.co.uk/allergy-treatment-information.htm Allergen binds to IgE, which links to mast cells, triggering release of histamine.

  15. Autoimmune Disease http://www.mctd.eu/images/AutoimmuneDisorder.jpg

  16. Cancer http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  17. http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlhttp://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  18. Stress Responses

  19. Obesity Trends* Among U.S. AdultsBRFSS, 1985 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% www.cdc.gov

  20. http://www.cancer.gov/cancertopics/factsheet/Risk/obesity

  21. Obesity Trends* Among U.S. AdultsBRFSS, 1986 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14%

  22. Obesity Trends* Among U.S. AdultsBRFSS, 1987 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14%

  23. Obesity Trends* Among U.S. AdultsBRFSS, 1988 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14%

  24. Obesity Trends* Among U.S. AdultsBRFSS, 1989 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14%

  25. Obesity Trends* Among U.S. AdultsBRFSS, 1990 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14%

  26. Obesity Trends* Among U.S. AdultsBRFSS, 1991 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19%

  27. Obesity Trends* Among U.S. AdultsBRFSS, 1992 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19%

  28. Obesity Trends* Among U.S. AdultsBRFSS, 1993 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19%

  29. Obesity Trends* Among U.S. AdultsBRFSS, 1994 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19%

  30. Obesity Trends* Among U.S. AdultsBRFSS, 1995 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19%

  31. Obesity Trends* Among U.S. AdultsBRFSS, 1996 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19%

  32. Obesity Trends* Among U.S. AdultsBRFSS, 1997 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% ≥20%

  33. Obesity Trends* Among U.S. AdultsBRFSS, 1998 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% ≥20%

  34. Obesity Trends* Among U.S. AdultsBRFSS, 1999 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% ≥20%

  35. Obesity Trends* Among U.S. AdultsBRFSS, 2000 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% ≥20%

  36. Obesity Trends* Among U.S. AdultsBRFSS, 2001 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

  37. Obesity Trends* Among U.S. AdultsBRFSS, 2002 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

  38. Obesity Trends* Among U.S. AdultsBRFSS, 2003 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

  39. Obesity Trends* Among U.S. AdultsBRFSS, 2004 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

  40. Obesity Trends* Among U.S. AdultsBRFSS, 2005 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person) No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

  41. http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1

  42. http://mednews.wustl.edu/tips/page/normal/8947.html

  43. The women in this study did not gain weight, but they did have an increase in abdominal fat http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&dpg=10

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