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Regenerative Medicine

Regenerative Medicine. Christine E. Schmidt, Ph.D. Biomedical Engineering The University of Texas at Austin. NIH/www.sutter-group.com. Potential US Patient Population. > 1 hundred million

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Regenerative Medicine

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  1. Regenerative Medicine Christine E. Schmidt, Ph.D. Biomedical Engineering The University of Texas at Austin NIH/www.sutter-group.com

  2. Potential US Patient Population > 1 hundred million … for conditions such as cardiovascular disease, autoimmune diseases, diabetes, cancer, neurodegenerative diseases, burns… The United States National Academies of Science report “Stem Cells and the Future of Regenerative Medicine”

  3. The Body Has Limited Ability to Regenerate www.net-planet.org; Dr. Jill Helms Lecture

  4. Digestive Tract Vessel Skin Bone Nerve Regenerative Medicine: Natural Healing

  5. CellsMaterialsBioactive Molecules Japan Tissue Engineering Co., Ltd. (J-TEC)

  6. Tissue Engineering

  7. The “Vacanti Mouse” - 1997 Cao et al., Plast Reconstr Surg, 100: 297-302, 1997

  8. Business Week 7/27/98

  9. Regenerative Medicine In the Media “Pixie Dust” Ground pig small intestinal submucosa (SIS) from Cook Biotech London Daily News; http://www.dailymail.co.uk

  10. Porcine SIS-Based Products Cook Biotech (PA)

  11. Acellular Regenerative Tissue Matrix AlloDerm, LifeCell (NJ) • Decellularized human cadaver dermis • Uses: hernia repair, breast recon-struction, soft tissue reconstruction, augmenting skin grafting

  12. Acellular Nerve Grafts Human Cadaver Nerve Avance, AxoGen (FL) Chemical Processing Acellular Scaffold • Used to treat traumatic and surgical damage to nerves in hands, arms, face, breast, prostate, etc.

  13. Decellularized Whole Organs?

  14. Need for Cells Adult mature cells Adult stem cells Neonatal cells (umbilical cord) Patient-derived vs. donor?

  15. Time, Aug 7, 2006

  16. Bioartificial Skin human keratinocytes Apligraf, Organogenesis (MA) collagen + human fibroblasts neonatal foreskin cells are ~non-immunogenic

  17. Osteocel Bone Therapy Donor-derived cellular bone matrix that retains native mesenchymal stem cells (MSCs) and osteoprogenitor cells Osteocel, Ace Surgical (MA)

  18. Challenges… Scientific challenges Regulatory hurdles Reducing costs Insurance coverage Point-of-care therapies

  19. Point-of-Care Cartilage Repair? CARTICEL, Genzyme (MA) 3-5 weeks (cell culture) CELLECT, DePuy (IN)

  20. Business Week 7/27/98

  21. http://www.bme.utexas.edu/faculty/schmidt

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