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Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology

Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology West China Medical school of Sichuan University. disorders of hematopoitic and lymphoid system red cell disorders anemia tumors white cell disorders* myeloid cells

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Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology

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  1. Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology West China Medical school of Sichuan University

  2. disorders of hematopoitic and lymphoid system red cell disorders anemia tumors white cell disorders* myeloid cells reactive : leukopenia, leukocytosis* tumors: lymphoid cells reactive tumors: lymphomas *

  3. Contents • 1.Diseases of lymphoid tissue • Inflammation • non-specific lymphadenitis • special infection： becteria fungus • parasites virus • Lymphoproliferative disorders, unknown causes • giant lymph node hyperplasia(Castleman’s disease) • sinus histiocytosis with massive lymphadenopathy • (Rosai-Dorfman disease) • Tumors*: • primary: lymphoid neoplasm* • secondary: metastatic tumors

  4. 2. Myeloid neoplasm • acute myeloblastic ( myelocytic ) leukemia • chronic myeloproliferative disorders • myelodysplastic syndrome, MDS

  5. histology and non-neoplastic disorders of lymph nodes

  6. TB

  7. cryptococcosis

  8. leishmaniosis

  9. lymphoid neoplasms

  10. lymphoid neoplasms • Definition • malignant tumors of immune system, including • lymphomas, lymphocytic leukemias and plasma cell • neoplasms. • involved organs and tissues • lymph nodes and extralymphocytic organs • bone marrow and peripheral blood • tumor cells lymphocytes – B, T and NK cell

  11. Classification • Hodgkin lymphoma, HL • Hodgkin Disease, HD • Non-Hodgkin lymphoma,NHL • B-cell neoplasms • T and NK-cell neoplasms • tumors of histiocyte and dendratic cells

  12. Hodgkin lymphoma,HL

  13. Pathologic changes • gross appearance: almost same as that of sarcoma • Histologic morphology: • archetecture of lymph node • partially or completely demolished • cells • tumor cells --- R-S cell and its variants • reactive inflammatory cells: lymphocytes • eosenophils • histocytes • fibrocytes and fibroblasts

  14. Subtypes of Hodgkin lymphoma 1. nodular lymphocyte predominanceHodgkin lymphoma, NLPHL 2. classical Hodgkin lymphoma,CHL lymphocyte-rich, LR mixed cellularity, MC lymphocyte depletion, LD nodular sclerosis, NS

  15. CD20

  16. diagnosis 1.biopsy and recognize RS cells carefully typical RS cells have a value for diagnosis of HL 2.immunohistochemical(IHC) staining CD15 CD30CD20

  17. CD15 HL CD30 immunostaining

  18. Non-Hodgkin lymphoma, NHL

  19. The classification on the tumors of hematopoitic and lymphoid tissues by WHO • B cell neoplasms • precusor B cell neoplasms • acute lymphoblastic leukemia / lymphoblasitc lymphoma • mature(peripheral) B cell neuplasms • T and NK cell neoplasmas • precusor T cell neoplasms • acute lymphoblastic leukemia / lymphoblasitc lymphoma • mature(peripheral) T and NK cell neuplasms

  20. key words 1.archetecture：Diffuse,D Follicular,F 2.cell size:large cell small cell blast 3.immunophenotype: T; B; NK; 4.sites related: mycosis fungoides, MF intestinal T-cell lymphoma, ITCL NK/T-cell lymphoma, nasal type

  21. Basic pathologic changes • Architecture of LN is partially or completely • demolished • relatively momnmorphic lymphoid tumor cell • infiltrated diffusely or follicularlly • the lymphoid tumor cells infiltrate the • capsule of LN and extrnodal soft tissues

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