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Adaptive Immunity

Adaptive Immunity.  Response occurs within days of the infection  Highly specific  Highly diverse  Memory component  Major cell types involved: T cells, B cells and antigen presenting cells. Humoral Immunity.

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Adaptive Immunity

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  1. Adaptive Immunity Response occurs within days of the infection Highly specific Highly diverse Memory component Major cell types involved: T cells, B cells and antigen presenting cells

  2. Humoral Immunity •Humoral immunity – Host defenses that are mediated by antibody present in the plasma, lymph and tissue fluids.

  3. Cellular Immunity •Cellular immunity – Host defenses that are mediated by antigen-specific T cells and various nonspecific cells of the immune system.

  4. T-cell Maturation

  5. The Major Histocompatibility Complex MHC Molecule classes encoded by numerous genes: •Class I –expressed by nearly all nucleated vertebrate cells; present antigens to TC cells. •Class II –expressed only by APCs; present antigens to TH cells. •Class III – distinct from class I and II; complement components, inflammatory cytokines.

  6. T Cell Receptor (TCR)

  7. T Cell Receptor (TCR)

  8. Antigen Presenting Cells

  9. Antigen Processing

  10. Antigen Processing (Cytosolic)

  11. Antigen Processing (Cytosolic)

  12. Antigen Processing (Endocytic)

  13. Antigen Processing Comparison

  14. Antigen Presentation/Signaling

  15. Antigen Presentation/Signaling

  16. Antigen Presentation/Signaling

  17. Cytotoxic Action

  18. Cytotoxic Action

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